Cardiac fibrosis in the pressure overloaded left and right ventricle as a therapeutic target
K Schimmel, K Ichimura, S Reddy, F Haddad… - Frontiers in …, 2022 - frontiersin.org
Myocardial fibrosis is a remodeling process of the extracellular matrix (ECM) following
cardiac stress.“Replacement fibrosis” is a term used to describe wound healing in the acute …
cardiac stress.“Replacement fibrosis” is a term used to describe wound healing in the acute …
Advances in miR-132-based biomarker and therapeutic potential in the cardiovascular system
K Xu, C Chen, Y Wu, M Wu, L Lin - Frontiers in Pharmacology, 2021 - frontiersin.org
Atherosclerotic cardiovascular disease and subsequent heart failure threaten global health
and impose a huge economic burden on society. MicroRNA-132 (miR-132), a regulatory …
and impose a huge economic burden on society. MicroRNA-132 (miR-132), a regulatory …
MicroRNA-132-3p alleviates neuron apoptosis and impairments of learning and memory abilities in Alzheimer's disease by downregulation of HNRNPU stabilized …
J Qu, X Xiong, G Hujie, J Ren, L Yan, L Ma - Cell Cycle, 2021 - Taylor & Francis
Alzheimer's disease (AD) is a progressive neuro-degenerative disease characterized by
dementia. MicroRNAs (miRNAs) are involved in many diseases, including AD. MiR-132-3p …
dementia. MicroRNAs (miRNAs) are involved in many diseases, including AD. MiR-132-3p …
[HTML][HTML] Dysregulation of inflammation, oxidative stress, and glucose metabolism-related genes and miRNAs in visceral adipose tissue of women with type 2 diabetes …
A Wróblewski, J Strycharz, K Oszajca… - … Medical Journal of …, 2023 - ncbi.nlm.nih.gov
Background Visceral adipose tissue (VAT), which has recently been recognized as an
endocrine organ, contributes to prediabetes and diabetes (T2DM) upon deregulated visceral …
endocrine organ, contributes to prediabetes and diabetes (T2DM) upon deregulated visceral …
New insights into the functions of MicroRNAs in cardiac fibrosis: from mechanisms to therapeutic strategies
Y Zhao, D Du, S Chen, Z Chen, J Zhao - Genes, 2022 - mdpi.com
Cardiac fibrosis is a significant global health problem associated with almost all types of
heart disease. Extensive cardiac fibrosis reduces tissue compliance and contributes to …
heart disease. Extensive cardiac fibrosis reduces tissue compliance and contributes to …
[HTML][HTML] Non-coding RNAs as new autophagy regulators in cancer progression
Q Lin, Y Shi, Z Liu, M Mehrpour, A Hamaï… - Biochimica et Biophysica …, 2022 - Elsevier
Recent advances highlight that non-coding RNAs (ncRNAs) are emerging as fundamental
regulators in various physiological as well as pathological processes by regulating macro …
regulators in various physiological as well as pathological processes by regulating macro …
CREB1 transcription-activated lncRNA PVT1 promotes cardiac fibrosis via miR-145/HCN1 axis
C Tian, S Hu, J Yu, W Li, P Li, H Huang - International Journal of Cardiology, 2022 - Elsevier
Background Cardiac fibrosis is a common pathological process of most cardiac diseases,
which may result in cardiac function impairment. Long noncoding RNAs (lncRNAs) have …
which may result in cardiac function impairment. Long noncoding RNAs (lncRNAs) have …
Long non‐coding RNA H19 promotes myoblast fibrogenesis via regulating the miR‐20a‐5p‐Tgfbr2 axis
Emerging evidence has indicated long non‐coding RNAs (lncRNAs) play important roles in
diverse biological processes, including fibrosis. Here, we report that lncRNA H19 is able to …
diverse biological processes, including fibrosis. Here, we report that lncRNA H19 is able to …
Non-coding RNAs: Important participants in cardiac fibrosis
Y Dong, N Peng, L Dong, S Tan… - Frontiers in Cardiovascular …, 2022 - frontiersin.org
Cardiac remodeling is a pathophysiological process activated by diverse cardiac stress,
which impairs cardiac function and leads to adverse clinical outcome. This remodeling partly …
which impairs cardiac function and leads to adverse clinical outcome. This remodeling partly …
The role of fibrosis in cardiomyopathies: an opportunity to develop novel biomarkers of disease activity
E Angeli, M Jordan, M Otto, SD Stojanović, M Karsdal… - Matrix Biology, 2024 - Elsevier
Cardiomyopathies encompass a spectrum of heart disorders with diverse causes and
presentations. Fibrosis stands out as a shared hallmark among various cardiomyopathies …
presentations. Fibrosis stands out as a shared hallmark among various cardiomyopathies …