Cardiac fibrosis in the pressure overloaded left and right ventricle as a therapeutic target

K Schimmel, K Ichimura, S Reddy, F Haddad… - Frontiers in …, 2022 - frontiersin.org
Myocardial fibrosis is a remodeling process of the extracellular matrix (ECM) following
cardiac stress.“Replacement fibrosis” is a term used to describe wound healing in the acute …

Advances in miR-132-based biomarker and therapeutic potential in the cardiovascular system

K Xu, C Chen, Y Wu, M Wu, L Lin - Frontiers in Pharmacology, 2021 - frontiersin.org
Atherosclerotic cardiovascular disease and subsequent heart failure threaten global health
and impose a huge economic burden on society. MicroRNA-132 (miR-132), a regulatory …

MicroRNA-132-3p alleviates neuron apoptosis and impairments of learning and memory abilities in Alzheimer's disease by downregulation of HNRNPU stabilized …

J Qu, X Xiong, G Hujie, J Ren, L Yan, L Ma - Cell Cycle, 2021 - Taylor & Francis
Alzheimer's disease (AD) is a progressive neuro-degenerative disease characterized by
dementia. MicroRNAs (miRNAs) are involved in many diseases, including AD. MiR-132-3p …

[HTML][HTML] Dysregulation of inflammation, oxidative stress, and glucose metabolism-related genes and miRNAs in visceral adipose tissue of women with type 2 diabetes …

A Wróblewski, J Strycharz, K Oszajca… - … Medical Journal of …, 2023 - ncbi.nlm.nih.gov
Background Visceral adipose tissue (VAT), which has recently been recognized as an
endocrine organ, contributes to prediabetes and diabetes (T2DM) upon deregulated visceral …

New insights into the functions of MicroRNAs in cardiac fibrosis: from mechanisms to therapeutic strategies

Y Zhao, D Du, S Chen, Z Chen, J Zhao - Genes, 2022 - mdpi.com
Cardiac fibrosis is a significant global health problem associated with almost all types of
heart disease. Extensive cardiac fibrosis reduces tissue compliance and contributes to …

[HTML][HTML] Non-coding RNAs as new autophagy regulators in cancer progression

Q Lin, Y Shi, Z Liu, M Mehrpour, A Hamaï… - Biochimica et Biophysica …, 2022 - Elsevier
Recent advances highlight that non-coding RNAs (ncRNAs) are emerging as fundamental
regulators in various physiological as well as pathological processes by regulating macro …

CREB1 transcription-activated lncRNA PVT1 promotes cardiac fibrosis via miR-145/HCN1 axis

C Tian, S Hu, J Yu, W Li, P Li, H Huang - International Journal of Cardiology, 2022 - Elsevier
Background Cardiac fibrosis is a common pathological process of most cardiac diseases,
which may result in cardiac function impairment. Long noncoding RNAs (lncRNAs) have …

Long non‐coding RNA H19 promotes myoblast fibrogenesis via regulating the miR‐20a‐5p‐Tgfbr2 axis

J Lin, Z Luo, S Liu, Q Chen, S Liu… - Clinical and …, 2021 - Wiley Online Library
Emerging evidence has indicated long non‐coding RNAs (lncRNAs) play important roles in
diverse biological processes, including fibrosis. Here, we report that lncRNA H19 is able to …

Non-coding RNAs: Important participants in cardiac fibrosis

Y Dong, N Peng, L Dong, S Tan… - Frontiers in Cardiovascular …, 2022 - frontiersin.org
Cardiac remodeling is a pathophysiological process activated by diverse cardiac stress,
which impairs cardiac function and leads to adverse clinical outcome. This remodeling partly …

The role of fibrosis in cardiomyopathies: an opportunity to develop novel biomarkers of disease activity

E Angeli, M Jordan, M Otto, SD Stojanović, M Karsdal… - Matrix Biology, 2024 - Elsevier
Cardiomyopathies encompass a spectrum of heart disorders with diverse causes and
presentations. Fibrosis stands out as a shared hallmark among various cardiomyopathies …