NRF2 and the Hallmarks of Cancer
The transcription factor NRF2 is the master regulator of the cellular antioxidant response.
Though recognized originally as a target of chemopreventive compounds that help prevent …
Though recognized originally as a target of chemopreventive compounds that help prevent …
[HTML][HTML] The genomics of oxidative DNA damage, repair, and resulting mutagenesis
AR Poetsch - Computational and structural biotechnology journal, 2020 - Elsevier
Reactive oxygen species are a constant threat to DNA as they modify bases with the risk of
disrupting genome function, inducing genome instability and mutation. Such risks are due to …
disrupting genome function, inducing genome instability and mutation. Such risks are due to …
Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling
Reactive oxygen species (ROS) are generated during mitochondrial oxidative metabolism
as well as in cellular response to xenobiotics, cytokines, and bacterial invasion. Oxidative …
as well as in cellular response to xenobiotics, cytokines, and bacterial invasion. Oxidative …
Oxidative stress and antioxidant defense
Reactive oxygen species (ROS) are produced by living organisms as a result of normal
cellular metabolism and environmental factors, such as air pollutants or cigarette smoke …
cellular metabolism and environmental factors, such as air pollutants or cigarette smoke …
[HTML][HTML] Hydrogen peroxide sensing, signaling and regulation of transcription factors
The regulatory mechanisms by which hydrogen peroxide (H 2 O 2) modulates the activity of
transcription factors in bacteria (OxyR and PerR), lower eukaryotes (Yap1, Maf1, Hsf1 and …
transcription factors in bacteria (OxyR and PerR), lower eukaryotes (Yap1, Maf1, Hsf1 and …
Redox dysregulation as a driver for DNA damage and its relationship to neurodegenerative diseases
Redox homeostasis refers to the balance between the production of reactive oxygen species
(ROS) as well as reactive nitrogen species (RNS), and their elimination by antioxidants. It is …
(ROS) as well as reactive nitrogen species (RNS), and their elimination by antioxidants. It is …
Crosstalk of reactive oxygen species and NF-κB signaling
NF-κB proteins are a family of transcription factors that are of central importance in
inflammation and immunity. NF-κB also plays important roles in other processes, including …
inflammation and immunity. NF-κB also plays important roles in other processes, including …
Nanotechnology for angiogenesis: opportunities and challenges
S Kargozar, F Baino, S Hamzehlou… - Chemical Society …, 2020 - pubs.rsc.org
Angiogenesis plays a critical role within the human body, from the early stages of life (ie,
embryonic development) to life-threatening diseases (eg, cancer, heart attack, stroke, wound …
embryonic development) to life-threatening diseases (eg, cancer, heart attack, stroke, wound …
Reactive oxygen species, antioxidants, and the mammalian thioredoxin system
J Nordberg, ESJ Arnér - Free radical biology and medicine, 2001 - Elsevier
Reactive oxygen species (ROS) are known mediators of intracellular signaling cascades.
Excessive production of ROS may, however, lead to oxidative stress, loss of cell function …
Excessive production of ROS may, however, lead to oxidative stress, loss of cell function …
[HTML][HTML] The cysteine proteome
The cysteine (Cys) proteome is a major component of the adaptive interface between the
genome and the exposome. The thiol moiety of Cys undergoes a range of biologic …
genome and the exposome. The thiol moiety of Cys undergoes a range of biologic …