NRF2 and the Hallmarks of Cancer

MR de la Vega, E Chapman, DD Zhang - Cancer cell, 2018 - cell.com
The transcription factor NRF2 is the master regulator of the cellular antioxidant response.
Though recognized originally as a target of chemopreventive compounds that help prevent …

[HTML][HTML] The genomics of oxidative DNA damage, repair, and resulting mutagenesis

AR Poetsch - Computational and structural biotechnology journal, 2020 - Elsevier
Reactive oxygen species are a constant threat to DNA as they modify bases with the risk of
disrupting genome function, inducing genome instability and mutation. Such risks are due to …

Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

PD Ray, BW Huang, Y Tsuji - Cellular signalling, 2012 - Elsevier
Reactive oxygen species (ROS) are generated during mitochondrial oxidative metabolism
as well as in cellular response to xenobiotics, cytokines, and bacterial invasion. Oxidative …

Oxidative stress and antioxidant defense

E Birben, UM Sahiner, C Sackesen, S Erzurum… - World allergy …, 2012 - Springer
Reactive oxygen species (ROS) are produced by living organisms as a result of normal
cellular metabolism and environmental factors, such as air pollutants or cigarette smoke …

[HTML][HTML] Hydrogen peroxide sensing, signaling and regulation of transcription factors

HS Marinho, C Real, L Cyrne, H Soares, F Antunes - Redox biology, 2014 - Elsevier
The regulatory mechanisms by which hydrogen peroxide (H 2 O 2) modulates the activity of
transcription factors in bacteria (OxyR and PerR), lower eukaryotes (Yap1, Maf1, Hsf1 and …

Redox dysregulation as a driver for DNA damage and its relationship to neurodegenerative diseases

S Shadfar, S Parakh, MS Jamali, JD Atkin - Translational …, 2023 - Springer
Redox homeostasis refers to the balance between the production of reactive oxygen species
(ROS) as well as reactive nitrogen species (RNS), and their elimination by antioxidants. It is …

Crosstalk of reactive oxygen species and NF-κB signaling

MJ Morgan, Z Liu - Cell research, 2011 - nature.com
NF-κB proteins are a family of transcription factors that are of central importance in
inflammation and immunity. NF-κB also plays important roles in other processes, including …

Nanotechnology for angiogenesis: opportunities and challenges

S Kargozar, F Baino, S Hamzehlou… - Chemical Society …, 2020 - pubs.rsc.org
Angiogenesis plays a critical role within the human body, from the early stages of life (ie,
embryonic development) to life-threatening diseases (eg, cancer, heart attack, stroke, wound …

Reactive oxygen species, antioxidants, and the mammalian thioredoxin system

J Nordberg, ESJ Arnér - Free radical biology and medicine, 2001 - Elsevier
Reactive oxygen species (ROS) are known mediators of intracellular signaling cascades.
Excessive production of ROS may, however, lead to oxidative stress, loss of cell function …

[HTML][HTML] The cysteine proteome

YM Go, JD Chandler, DP Jones - Free Radical Biology and Medicine, 2015 - Elsevier
The cysteine (Cys) proteome is a major component of the adaptive interface between the
genome and the exposome. The thiol moiety of Cys undergoes a range of biologic …