[HTML][HTML] Ethical considerations regarding animal experimentation
Animal experimentation is widely used around the world for the identification of the root
causes of various diseases in humans and animals and for exploring treatment options …
causes of various diseases in humans and animals and for exploring treatment options …
[HTML][HTML] Reliability of common mouse behavioural tests of anxiety: A systematic review and meta-analysis on the effects of anxiolytics
M Rosso, R Wirz, AV Loretan, NA Sutter… - Neuroscience & …, 2022 - Elsevier
The validity of widely used rodent behavioural tests of anxiety has been questioned, as they
often fail to produce consistent results across independent replicate studies. In this study, we …
often fail to produce consistent results across independent replicate studies. In this study, we …
[HTML][HTML] The continued need for animals to advance brain research
Policymakers aim to move toward animal-free alternatives for scientific research and have
introduced very strict regulations for animal research. We argue that, for neuroscience …
introduced very strict regulations for animal research. We argue that, for neuroscience …
[HTML][HTML] The contribution of veterinary public health to the management of the COVID-19 pandemic from a One Health perspective
M Ferri, M Lloyd-Evans - One Health, 2021 - Elsevier
The human coronavirus disease 2019 (COVID-19) pandemic represents one of the greatest
public health crises in recent history, which has caused unprecedented and massive …
public health crises in recent history, which has caused unprecedented and massive …
Distinct spatial arrangements of ACE2 and TMPRSS2 expression in Syrian hamster lung lobes dictates SARS-CoV-2 infection patterns
I Tomris, KM Bouwman, Y Adolfs, D Noack… - PLoS …, 2022 - journals.plos.org
SARS-CoV-2 attaches to angiotensin-converting enzyme 2 (ACE2) to gain entry into cells
after which the spike protein is cleaved by the transmembrane serine protease 2 …
after which the spike protein is cleaved by the transmembrane serine protease 2 …
Scientific inertia in animal-based research in biomedicine
S Lohse - Studies in History and Philosophy of Science Part A, 2021 - Elsevier
Despite aspirations to substitute animal experimentation with alternative methods and recent
progress in the area of non-animal approaches, such as organoïds and organ (s)-on-a-chip …
progress in the area of non-animal approaches, such as organoïds and organ (s)-on-a-chip …
Animal models for studying coronavirus infections and developing antiviral agents and vaccines
In addition to severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East
respiratory syndrome coronavirus (MERS-CoV), SARS-CoV-2 has become the third deadly …
respiratory syndrome coronavirus (MERS-CoV), SARS-CoV-2 has become the third deadly …
The fate of surplus laboratory animals: minimizing the production of surplus animals has greatest potential to reduce the number of laboratory animals
H Wewetzer, T Wagenknecht, B Bert, G Schönfelder - EMBO reports, 2023 - embopress.org
Modern medicine is not possible without animal testing. Whether it is the novel
immunotherapies against cancer or the vaccines against SARS-CoV2, biomedical research …
immunotherapies against cancer or the vaccines against SARS-CoV2, biomedical research …
Do we still need animals? Surveying the role of animal‐free models in Alzheimer's and Parkinson's disease research
The use of animals in neuroscience and biomedical research remains controversial. Policy
is built around the “3R” principle of “Refining, Reducing and Replacing” animal experiments …
is built around the “3R” principle of “Refining, Reducing and Replacing” animal experiments …
Genes, environments, and phenotypic plasticity in immunology
For most of its history, immunology has sought to control environmental variation to establish
genetic causality. As with all biological traits though, variation among individuals arises by …
genetic causality. As with all biological traits though, variation among individuals arises by …