By imposing saltatory conduction on the nervous impulse, the principal role of the myelin
sheath is to allow the faster propagation of action potentials along the axons which it …

Three genes commonly causing Charcot–Marie–Tooth disease (CMT) encode myelin‐
related proteins: peripheral myelin protein 22 (PMP22), myelin protein zero (MPZ) and …

X-linked Charcot-Marie-Tooth disease (CMTX) is a form of hereditary neuropathy with
demyelination. Recently, this disorder was mapped to chromosome Xq13. 1. The gene for …

We have examined the expression of a gap junction protein, connexin32 (Cx32), in
Schwann cells and oligodendrocytes. In peripheral nerve, Cx32 is found in the paranodal …

The Schwann cell myelin sheath is a multilamellar structure with distinct structural domains
in which different proteins are localized. Intracellular dye injection and video microscopy …

Axonal degeneration contributes to clinical disability in the acquired demyelinating disease
multiple sclerosis. Axonal degeneration occurs during acute attacks, associated with …

Mutations in the gene encoding the gap junction protein connexin32 (Cx32) cause X‐linked
Charcot‐Marie‐Tooth disease (CMTX), a common form of inherited demyelinating …

Mutations in the GJB1 gene, encoding the gap junction (GJ) protein connexin32 (Cx32),
cause X-linked Charcot-Marie-Tooth disease (CMT1X), an inherited demyelinating …

Abstract Development of peripheral nervous system (PNS) myelin involves a coordinated
series of events between growing axons and the Schwann cell (SC) progenitors that will …

Abstract Charcot–Marie–Tooth disease (CMT) is the most frequent form of inherited
neuropathy with great variety of phenotypes, inheritance patterns, and causative genes …