Engineering ACE2 decoy receptors to combat viral escapability
T Arimori, N Ikemura, T Okamoto, J Takagi… - Trends in …, 2022 - cell.com
Decoy receptor proteins that trick viruses to bind to them should be resistant to viral escape
because viruses that require entry receptors cannot help but bind decoy receptors …
because viruses that require entry receptors cannot help but bind decoy receptors …
[HTML][HTML] Passive immunotherapy against SARS-CoV-2: from plasma-based therapy to single potent antibodies in the race to stay ahead of the variants
The COVID-19 pandemic is now approaching 2 years old, with more than 440 million people
infected and nearly six million dead worldwide, making it the most significant pandemic …
infected and nearly six million dead worldwide, making it the most significant pandemic …
[HTML][HTML] SARS-CoV-2 variant prediction and antiviral drug design are enabled by RBD in vitro evolution
J Zahradník, S Marciano, M Shemesh, E Zoler… - Nature …, 2021 - nature.com
SARS-CoV-2 variants of interest and concern will continue to emerge for the duration of the
COVID-19 pandemic. To map mutations in the receptor-binding domain (RBD) of the spike …
COVID-19 pandemic. To map mutations in the receptor-binding domain (RBD) of the spike …
Multivalent designed proteins neutralize SARS-CoV-2 variants of concern and confer protection against infection in mice
New variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continue to
arise and prolong the coronavirus disease 2019 (COVID-19) pandemic. Here, we used a …
arise and prolong the coronavirus disease 2019 (COVID-19) pandemic. Here, we used a …
[PDF][PDF] SARS-CoV-2 simulations go exascale to capture spike opening and reveal cryptic pockets across the proteome
MI Zimmerman, G Bowman - Biophysical Journal, 2021 - cell.com
The SARS-CoV-2/COVID-19 pandemic continues to threaten global health and
socioeconomic stability. Experiments have revealed snapshots of many viral components …
socioeconomic stability. Experiments have revealed snapshots of many viral components …
[HTML][HTML] Engineered ACE2 receptor therapy overcomes mutational escape of SARS-CoV-2
Y Higuchi, T Suzuki, T Arimori, N Ikemura… - Nature …, 2021 - nature.com
SARS-CoV-2 has mutated during the global pandemic leading to viral adaptation to
medications and vaccinations. Here we describe an engineered human virus receptor …
medications and vaccinations. Here we describe an engineered human virus receptor …
[HTML][HTML] A trimeric human angiotensin-converting enzyme 2 as an anti-SARS-CoV-2 agent
Effective intervention strategies are urgently needed to control the COVID-19 pandemic.
Human angiotensin-converting enzyme 2 (ACE2) is a membrane-bound carboxypeptidase …
Human angiotensin-converting enzyme 2 (ACE2) is a membrane-bound carboxypeptidase …
Engineering extracellular vesicles enriched with palmitoylated ACE2 as COVID‐19 therapy
F Xie, P Su, T Pan, X Zhou, H Li, H Huang… - Advanced …, 2021 - Wiley Online Library
Abstract Angiotensin converting enzyme 2 (ACE2) is a key receptor present on cell surfaces
that directly interacts with the viral spike (S) protein of the severe acute respiratory syndrome …
that directly interacts with the viral spike (S) protein of the severe acute respiratory syndrome …
[HTML][HTML] Glycated ACE2 receptor in diabetes: open door for SARS-COV-2 entry in cardiomyocyte
Rationale About 50% of hospitalized coronavirus disease 2019 (COVID-19) patients with
diabetes mellitus (DM) developed myocardial damage. The mechanisms of direct SARS …
diabetes mellitus (DM) developed myocardial damage. The mechanisms of direct SARS …
Potential detrimental role of soluble ACE2 in severe COVID‐19 comorbid patients
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) enters the host cell by
binding to angiotensin‐converting enzyme 2 (ACE2) receptor. Other important proteins …
binding to angiotensin‐converting enzyme 2 (ACE2) receptor. Other important proteins …