[HTML][HTML] Translating complexity and heterogeneity of pancreatic tumor: 3D in vitro to in vivo models

MA Heinrich, AMRH Mostafa, JP Morton… - Advanced drug delivery …, 2021 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive type of cancer with
an overall survival rate of less than 7-8%, emphasizing the need for novel effective …

Devices and techniques used to obtain and analyze three‐dimensional cell cultures

G Agrawal, A Ramesh, P Aishwarya… - Biotechnology …, 2021 - Wiley Online Library
Cell cultures are indispensable for both basic and applied research. Advancements in cell
culture and analysis increase their utility for basic research and translational applications. A …

Calcium, mitochondria and the initiation of acute pancreatitis

SJ Pandol, RA Gottlieb - Pancreatology, 2022 - Elsevier
Acute pancreatitis is characterized by necrosis of its parenchymal cells and influx and
activation of inflammatory cells that further promote injury and necrosis. This review is …

Animal models to study the role of pulmonary intravascular macrophages in spontaneous and induced acute pancreatitis

V Vrolyk, B Singh - Cell and tissue research, 2020 - Springer
Acute necrotizing pancreatitis (ANP) is a common gastrointestinal cause of emergency
admissions in dogs and humans and can lead to a systemic inflammatory response …

Chemical pancreatectomy treats chronic pancreatitis while preserving endocrine function in preclinical models

M Saleh, K Sharma, R Kalsi, J Fusco… - The Journal of …, 2021 - Am Soc Clin Investig
Chronic pancreatitis affects over 250,000 people in the US and millions worldwide. It is
associated with chronic debilitating pain, pancreatic exocrine failure, and high risk of …

[HTML][HTML] Experimental pancreatitis is characterized by rapid T cell activation, Th2 differentiation that parallels disease severity, and improvement after CD4+ T cell …

J Glaubitz, A Wilden, C van den Brandt, FU Weiss… - Pancreatology, 2020 - Elsevier
Background Acute pancreatitis is a gastrointestinal disorder of high incidence resulting in life
threatening complications in up to 20% of patients. Its severe form is characterized by an …

Xiao Chai Hu Tang alleviates the pancreatic tumorigenesis via improving the mtDNA N6-Methyladenine modification mediated mitochondrial dysfunction in Syrian …

J Cai, W Shen, G Zhang, X Li, H Shen, W Li, C Tan… - Phytomedicine, 2023 - Elsevier
Abstract Background Pancreatic intraepithelial neoplasia (PanIN) is the most common
precursor lesion of pancreatic ductal adenocarcinoma (PDAC), which is a highly malignant …

Barriers and research priorities for implementing precision medicine

DC Whitcomb - Pancreas, 2019 - journals.lww.com
The vision of precision medicine is to prescribe the right treatment to the right patient in the
right dose at the right time and to expect the optimal outcome. 1 Precision medicine, as …

Serum biomarkers for chronic pancreatitis pain patterns

JL Saloman, G Tang, KM Stello, KE Hall, X Wang… - Pancreatology, 2021 - Elsevier
Objectives Chronic pancreatitis (CP) is associated with debilitating refractory pain. Distinct
subtypes of CP pain have been previously characterized based on severity (none, mild …

Uncovering the pharmacology of Xiaochaihu decoction in the treatment of acute pancreatitis based on the network pharmacology

L Zhan, J Pu, Y Hu, P Xu, W Liang… - BioMed Research …, 2021 - Wiley Online Library
Background. Xiaochaihu decoction (XD) has demonstrated the pharmacodynamics on acute
pancreatitis. This study was aimed at investigating the material and molecular basis of …