Proteins are composed of evolutionary units called domains; the majority of proteins consist
of at least two domains. These domains and nature of their interactions determine the …

Analyses of genomes show that more than 70% of eukaryotic proteins are composed of
multiple domains. However, most studies of protein folding focus on individual domains and …

Of the sequence comparison methods, profile-based methods perform with greater
selectively than those that use pairwise comparisons. Of the profile methods, hidden Markov …

Most proteins have been formed by gene duplication, recombination, and divergence.
Proteins of known structure can be matched to about 50% of genome sequences, and these …

We are beginning to elucidate transcriptional regulatory networks on a large scale and to
understand some of the structural principles of these networks,, but the evolutionary …

There is a limited repertoire of domain families that are duplicated and combined in different
ways to form the set of proteins in a genome. Proteins are gene products, and at the level of …

The most detailed information presently available for an organism's transcriptional
regulation network is that for the prokaryote Escherichia coli. In order to gain insight into the …

Background S-adenosylmethionine is a source of diverse chemical groups used in
biosynthesis and modification of virtually every class of biomolecules. The most notable …

Sequencing DNA from several organisms has revealed that duplication and drift of existing
genes have primarily moulded the contents of a given genome. Though the effect of …

Intrinsically disordered regions, terminal tails, and flexible linkers are abundant in DNA-
binding proteins and play a crucial role by increasing the affinity and specificity of DNA …