Understanding nanoparticle endocytosis to improve targeting strategies in nanomedicine

MS de Almeida, E Susnik, B Drasler… - Chemical society …, 2021 - pubs.rsc.org
Nanoparticles (NPs) have attracted considerable attention in various fields, such as
cosmetics, the food industry, material design, and nanomedicine. In particular, the fast …

Concepts of nanoparticle cellular uptake, intracellular trafficking, and kinetics in nanomedicine

ND Donahue, H Acar, S Wilhelm - Advanced drug delivery reviews, 2019 - Elsevier
Nanoparticle-based therapeutics and diagnostics are commonly referred to as
nanomedicine and may significantly impact the future of healthcare. However, the clinical …

Engineering nano-drug biointerface to overcome biological barriers toward precision drug delivery

S Waheed, Z Li, F Zhang, A Chiarini, U Armato… - Journal of …, 2022 - Springer
The rapid advancement of nanomedicine and nanoparticle (NP) materials presents novel
solutions potentially capable of revolutionizing health care by improving efficacy …

Cellular uptake of nanoparticles: journey inside the cell

S Behzadi, V Serpooshan, W Tao, MA Hamaly… - Chemical society …, 2017 - pubs.rsc.org
Nanoscale materials are increasingly found in consumer goods, electronics, and
pharmaceuticals. While these particles interact with the body in myriad ways, their beneficial …

The biomolecular corona of lipid nanoparticles for gene therapy

V Francia, RM Schiffelers, PR Cullis… - Bioconjugate …, 2020 - ACS Publications
Gene therapy holds great potential for treating almost any disease by gene silencing, protein
expression, or gene correction. To efficiently deliver the nucleic acid payload to its target …

Protein corona: a new approach for nanomedicine design

VH Nguyen, BJ Lee - International journal of nanomedicine, 2017 - Taylor & Francis
After administration of nanoparticle (NP) into biological fluids, an NP–protein complex is
formed, which represents the “true identity” of NP in our body. Hence, protein–NP interaction …

Corona composition can affect the mechanisms cells use to internalize nanoparticles

V Francia, K Yang, S Deville, C Reker-Smit, I Nelissen… - ACS …, 2019 - ACS Publications
Nanosized objects, such as nanoparticles and other drug carriers used in nanomedicine,
once in contact with biological environments are modified by adsorption of biomolecules on …

Entry of nanoparticles into cells: The importance of nanoparticle properties

J Zhao, MH Stenzel - Polymer Chemistry, 2018 - pubs.rsc.org
Knowledge of the interactions between nanoparticles (NPs) and cell membranes is of great
importance for the design of safe and efficient nanomedicines. Extensive studies aimed at …

In vivo formation of protein corona on gold nanoparticles. The effect of their size and shape

R García-Álvarez, M Hadjidemetriou… - Nanoscale, 2018 - pubs.rsc.org
The efficacy of drug delivery and other nanomedicine-related therapies largely relies on the
ability of nanoparticles to reach the target organ. However, when nanoparticles are injected …

Biological identity of nanoparticles in vivo: clinical implications of the protein corona

G Caracciolo, OC Farokhzad, M Mahmoudi - Trends in biotechnology, 2017 - cell.com
Despite the advances in biomedical applications of nanoparticle (NP) and numerous
publications, few NPs have made it to clinical trials and even fewer have reached clinical …