Mammalian development demands precision. Millions of molecules must be properly
located in temporal order, and their function regulated, to orchestrate important steps in cell …

The trace element zinc (Zn) binds to over ten percent of proteins in eukaryotic cells. Zn
flexible chemistry allows it to regulate the activity of hundreds of enzymes and influence …

Zinc is a tightly regulated trace mineral element playing critical roles in growth, immunity,
neurodevelopment, and synaptic and hormonal signaling. Although severe dietary zinc …

This study examined the associations between concentrations of cobalt (Co), iron (Fe),
manganese (Mn), molybdenum (Mo), selenium (Se), and zinc (Zn) in placental tissue and …

p53 is one of the most intensively studied tumor suppressors. It transcriptionally regulates a
broad range of genes to modulate a series of cellular events, including DNA damage repair …

Background Neural tube defects are a pressing public health concern despite advances in
prevention from folic acid-based strategies. Numerous chemicals, in particular arsenic, have …

Function of the mature central nervous system (CNS) requires a substantial proportion of the
body's energy consumption. During development, the CNS anlage must maintain its …

Glyphosate is the most popular herbicide used in modern agriculture, and its use has been
increasing substantially since its introduction. Accordingly, glyphosate exposure from food …

Abstract Neural Tube Defects are the most typical congenital malformations, with almost
300,000 cases annually worldwide. The incidence varies amongst geographical ranges …

Neural tube defects (NTDs) are among the most common birth defects, with a prevalence of
close to 19 per 10,000 births worldwide. The etiology of NTDs is complex involving the …