Highlights•Nanobodies (Nbs) are camelid-derived single-domain antibodies.•Nbs have
powerful binding and inhibitory capacity with great therapeutic potential.•Nbs are used in …

Optical imaging has become an indispensable technology in the clinic. The molecular
design of cell-targeted and highly sensitive materials, the validation of specific disease …

Nanobodies are the recombinant variable domains of heavy-chain-only antibodies, with
many unique properties such as small size, excellent solubility, superior stability, quick …

The use of antibody-based therapeutics has proven very promising for clinical applications
in cancer patients, with multiple examples of antibodies and antibody–drug conjugates …

Since the serendipitous discovery 20 years ago of bona fide camelid heavy-chain
antibodies, their single-domain antigen-binding fragments, known as VHHs or nanobodies …

A compound's intratumoural distribution is an important determinant for the effectiveness of
molecular therapy or imaging. Antibodies (Abs), though often used in the design of targeted …

Cancer is a major threat to human health. Diagnosis and treatment using precision medicine
is expected to be an effective method for preventing the initiation and progression of cancer …

In spite of the successful use of monoclonal antibodies (mAbs) in clinic for tumor treatment,
their applications are still hampered in therapeutic development due to limitations, such as …

The development of tumor-targeted therapies using monoclonal antibodies has been
successful during the last 30 years. Nevertheless, the efficacy of antibody-based therapy is …

Variable domains of heavy chain-only antibodies (VHH), also known as nanobodies (Nbs),
are monomeric antigen-binding domains derived from the camelid heavy chain-only …