Image analysis using multiplex immunofluorescence (mIF) to detect different proteins in a
single tissue section has revolutionized immunohistochemical methods in recent years. With …

Increasing evidence suggests that besides mutational and molecular alterations, the
immune component of the tumor microenvironment also substantially impacts tumor …

With the success of immunotherapy in cancer, understanding the tumor immune
microenvironment (TIME) has become increasingly important; however in pediatric brain …

Tertiary lymphoid structures (TLSs) are defined as lymphoid aggregates formed in non-
hematopoietic organs under pathological conditions. Similar to secondary lymphoid organs …

Pediatric low-grade gliomas (pLGGs) are the most common brain tumor in children and are
associated with lifelong clinical morbidity. Relative to their high-grade adult counterparts or …

Background: Although many works have supported the utility of PET radiomics, several
authors have raised concerns over the robustness and replicability of the results. This study …

The brain tumor microenvironment contains numerous distinct types of nonneoplastic cells,
which each serve a diverse set of roles relevant to the formation, maintenance, and …

Pediatric high-grade gliomas (pHGGs), including hemispheric pHGGs and diffuse midline
gliomas (DMGs), harbor mutually exclusive tumor location-specific histone mutations. Using …

Over the past decade, remarkable progress has been made towards elucidating the origin
and genomic landscape of childhood high-grade brain tumours. It has become evident that …

Purpose Tumor cells thrive by adapting to the signals in their microenvironment. To adapt,
cancer cells activate signaling and transcriptional programs and migrate to establish micro …