Structure, dynamics, assembly, and evolution of protein complexes

JA Marsh, SA Teichmann - Annual review of biochemistry, 2015 - annualreviews.org
The assembly of individual proteins into functional complexes is fundamental to nearly all
biological processes. In recent decades, many thousands of homomeric and heteromeric …

The aspartic acid metabolic pathway, an exciting and essential pathway in plants

RA Azevedo, M Lancien, PJ Lea - Amino acids, 2006 - Springer
Aspartate is the common precursor of the essential amino acids lysine, threonine,
methionine and isoleucine in higher plants. In addition, aspartate may also be converted to …

Inhibition of lysine biosynthesis: an evolving antibiotic strategy

CA Hutton, MA Perugini, JA Gerrard - Molecular BioSystems, 2007 - pubs.rsc.org
Bacterial biosynthesis of lysine has come under increased scrutiny as a target for novel
antibacterial agents as it provides lysine for protein synthesis and both lysine and meso …

Functional determinants of protein assembly into homomeric complexes

LT Bergendahl, JA Marsh - Scientific reports, 2017 - nature.com
Approximately half of proteins with experimentally determined structures can interact with
other copies of themselves and assemble into homomeric complexes, the overwhelming …

The emergence of protein complexes: quaternary structure, dynamics and allostery

T Perica, JA Marsh, FL Sousa, E Natan, LJ Colwell… - 2012 - portlandpress.com
All proteins require physical interactions with other proteins in order to perform their
functions. Most of them oligomerize into homomers, and a vast majority of these homomers …

The coordinated action of the enzymes in the L-lysine biosynthetic pathway and how to inhibit it for antibiotic targets

S Muduli, S Karmakar, S Mishra - Biochimica et Biophysica Acta (BBA) …, 2023 - Elsevier
Background Antimicrobial resistance is a global health issue that requires immediate
attention in terms of new antibiotics and new antibiotic targets. The l-lysine biosynthesis …

Identification and characterization of L-arabonate dehydratase, L-2-keto-3-deoxyarabonate dehydratase, and L-arabinolactonase involved in an alternative pathway of …

S Watanabe, N Shimada, K Tajima, T Kodaki… - Journal of Biological …, 2006 - ASBMB
Azospirillum brasiliense possesses an alternative pathway of l-arabinose metabolism,
different from the known bacterial and fungal pathways. In the preceding articles, we …

Structure and evolution of a novel dimeric enzyme from a clinically important bacterial pathogen

BR Burgess, RCJ Dobson, MF Bailey… - Journal of Biological …, 2008 - ASBMB
Dihydrodipicolinate synthase (DHDPS) catalyzes the first committed step of the lysine
biosynthetic pathway. The tetrameric structure of DHDPS is thought to be essential for …

Evolution of protein quaternary structure in response to selective pressure for increased thermostability

NJ Fraser, JW Liu, PD Mabbitt, GJ Correy… - Journal of Molecular …, 2016 - Elsevier
Oligomerization has been suggested to be an important mechanism for increasing or
maintaining the thermostability of proteins. Although it is evident that protein–protein …

The crystal structures of native and (S)-lysine-bound dihydrodipicolinate synthase from Escherichia coli with improved resolution show new features of biological …

RCJ Dobson, MDW Griffin, GB Jameson… - … Section D: Biological …, 2005 - journals.iucr.org
Dihydrodipicolinate synthase (DHDPS) mediates the key first reaction common to the
biosynthesis of (S)-lysine and meso-diaminopimelate. The activity of DHDPS is allosterically …