Structure, dynamics, assembly, and evolution of protein complexes
JA Marsh, SA Teichmann - Annual review of biochemistry, 2015 - annualreviews.org
The assembly of individual proteins into functional complexes is fundamental to nearly all
biological processes. In recent decades, many thousands of homomeric and heteromeric …
biological processes. In recent decades, many thousands of homomeric and heteromeric …
The aspartic acid metabolic pathway, an exciting and essential pathway in plants
RA Azevedo, M Lancien, PJ Lea - Amino acids, 2006 - Springer
Aspartate is the common precursor of the essential amino acids lysine, threonine,
methionine and isoleucine in higher plants. In addition, aspartate may also be converted to …
methionine and isoleucine in higher plants. In addition, aspartate may also be converted to …
Inhibition of lysine biosynthesis: an evolving antibiotic strategy
Bacterial biosynthesis of lysine has come under increased scrutiny as a target for novel
antibacterial agents as it provides lysine for protein synthesis and both lysine and meso …
antibacterial agents as it provides lysine for protein synthesis and both lysine and meso …
Functional determinants of protein assembly into homomeric complexes
LT Bergendahl, JA Marsh - Scientific reports, 2017 - nature.com
Approximately half of proteins with experimentally determined structures can interact with
other copies of themselves and assemble into homomeric complexes, the overwhelming …
other copies of themselves and assemble into homomeric complexes, the overwhelming …
The emergence of protein complexes: quaternary structure, dynamics and allostery
All proteins require physical interactions with other proteins in order to perform their
functions. Most of them oligomerize into homomers, and a vast majority of these homomers …
functions. Most of them oligomerize into homomers, and a vast majority of these homomers …
The coordinated action of the enzymes in the L-lysine biosynthetic pathway and how to inhibit it for antibiotic targets
Background Antimicrobial resistance is a global health issue that requires immediate
attention in terms of new antibiotics and new antibiotic targets. The l-lysine biosynthesis …
attention in terms of new antibiotics and new antibiotic targets. The l-lysine biosynthesis …
Identification and characterization of L-arabonate dehydratase, L-2-keto-3-deoxyarabonate dehydratase, and L-arabinolactonase involved in an alternative pathway of …
S Watanabe, N Shimada, K Tajima, T Kodaki… - Journal of Biological …, 2006 - ASBMB
Azospirillum brasiliense possesses an alternative pathway of l-arabinose metabolism,
different from the known bacterial and fungal pathways. In the preceding articles, we …
different from the known bacterial and fungal pathways. In the preceding articles, we …
Structure and evolution of a novel dimeric enzyme from a clinically important bacterial pathogen
BR Burgess, RCJ Dobson, MF Bailey… - Journal of Biological …, 2008 - ASBMB
Dihydrodipicolinate synthase (DHDPS) catalyzes the first committed step of the lysine
biosynthetic pathway. The tetrameric structure of DHDPS is thought to be essential for …
biosynthetic pathway. The tetrameric structure of DHDPS is thought to be essential for …
Evolution of protein quaternary structure in response to selective pressure for increased thermostability
NJ Fraser, JW Liu, PD Mabbitt, GJ Correy… - Journal of Molecular …, 2016 - Elsevier
Oligomerization has been suggested to be an important mechanism for increasing or
maintaining the thermostability of proteins. Although it is evident that protein–protein …
maintaining the thermostability of proteins. Although it is evident that protein–protein …
The crystal structures of native and (S)-lysine-bound dihydrodipicolinate synthase from Escherichia coli with improved resolution show new features of biological …
Dihydrodipicolinate synthase (DHDPS) mediates the key first reaction common to the
biosynthesis of (S)-lysine and meso-diaminopimelate. The activity of DHDPS is allosterically …
biosynthesis of (S)-lysine and meso-diaminopimelate. The activity of DHDPS is allosterically …