Mass spectrometry-based techniques to elucidate the sugar code

M Grabarics, M Lettow, C Kirschbaum, K Greis… - Chemical …, 2021 - ACS Publications
Cells encode information in the sequence of biopolymers, such as nucleic acids, proteins,
and glycans. Although glycans are essential to all living organisms, surprisingly little is …

[HTML][HTML] Applications of infrared spectroscopy in polysaccharide structural analysis: Progress, challenge and perspective

T Hong, JY Yin, SP Nie, MY Xie - Food chemistry: X, 2021 - Elsevier
Polysaccharides are important biomacromolecules with numerous beneficial functions and a
wide range of industrial applications. Functions and properties of polysaccharides are …

Advances in mass spectrometry‐based glycomics—An update covering the period 2017–2021

KB Donohoo, J Wang, M Goli, A Yu, W Peng… - …, 2022 - Wiley Online Library
The wide variety of chemical properties and biological functions found in proteins is attained
via post‐translational modifications like glycosylation. Covalently bonded to proteins …

Toward high-throughput cryogenic IR fingerprinting of mobility-separated glycan isomers

S Warnke, A Ben Faleh, TR Rizzo - ACS measurement science …, 2021 - ACS Publications
Infrared (IR) spectroscopy is a powerful tool used to infer detailed structural information on
molecules, often in conjunction with quantum-chemical calculations. When applied to …

Characterization of Elusive Reaction Intermediates Using Infrared Ion Spectroscopy: Application to the Experimental Characterization of Glycosyl Cations

F Braak, H Elferink, KJ Houthuijs… - Accounts of Chemical …, 2022 - ACS Publications
Conspectus A detailed understanding of the reaction mechanism (s) leading to
stereoselective product formation is crucial to understanding and predicting product …

Multistage ion mobility spectrometry combined with infrared spectroscopy for glycan analysis

P Bansal, A Ben Faleh, S Warnke… - Journal of the American …, 2023 - ACS Publications
The structural complexity of glycans makes their characterization challenging, not only
because of the presence of various isomeric forms of the precursor molecule but also …

The combination of laser photodissociation, action spectroscopy, and mass spectrometry to identify and separate isomers

SJP Marlton, AJ Trevitt - Chemical Communications, 2022 - pubs.rsc.org
The separation and detection of isomers remains a challenge for many areas of mass
spectrometry. This article highlights laser photodissociation and ion mobility strategies that …

Gas-phase infrared spectroscopy of glycans and glycoconjugates

K Greis, C Kirschbaum, G von Helden… - Current Opinion in …, 2022 - Elsevier
Glycans are intrinsically complex biomolecules that pose particular analytical challenges.
Standard workflows for glycan analysis are based on mass spectrometry, often coupled with …

Metal adduction in mass spectrometric analyses of carbohydrates and glycoconjugates

DT Gass, AV Quintero, JB Hatvany… - Mass Spectrometry …, 2024 - Wiley Online Library
Glycans, carbohydrates, and glycoconjugates are involved in many crucial biological
processes, such as disease development, immune responses, and cell–cell recognition …

Recent advances in high‐resolution traveling wave‐based ion mobility separations coupled to mass spectrometry

CN Naylor, G Nagy - Mass Spectrometry Reviews, 2024 - Wiley Online Library
Recently, ion mobility spectrometry‐mass spectrometry (IMS‐MS) has become more readily
incorporated into various omics‐based workflows. These growing applications are due to …