Synergistic protective effects of lycopene and N-acetylcysteine against cisplatin-induced hepatorenal toxicity in rats

A Elsayed, A Elkomy, R Elkammar, G Youssef… - Scientific Reports, 2021 - nature.com
Cisplatin (CP) is one of the most frequently used chemotherapy agents. The objective of this
design was to determine the ameliorative effect of lycopene (LP) and/or N-acetylcysteine …

Melatonin and cisplatin co-treatment against cancer: a mechanistic review of their synergistic effects and melatonin's protective actions

M Rafiyan, A Davoodvandi, RJ Reiter… - … -Research and Practice, 2024 - Elsevier
Combination chemotherapy appears to be a preferable option for some cancer patients,
especially when the medications target multiple pathways of oncogenesis; individuals …

Anti-kindling effect of Ginkgo biloba leaf extract and L-carnitine in the pentylenetetrazol model of epilepsy

AE Essawy, SA El-Sayed, E Tousson… - … Science and Pollution …, 2022 - Springer
Epilepsy is one of the most common serious brain disorders, affecting about 1% of the
population all over the world. Ginkgo biloba extract (GbE) and L-carnitine (LC) reportedly …

Testicular toxicity of cisplatin in rats: ameliorative effect of lycopene and N-acetylcysteine

A Elsayed, A Elkomy, M Alkafafy, R Elkammar… - … Science and Pollution …, 2022 - Springer
Lycopene (LP) and N-acetylcysteine (NAC) protective effects were assessed for testicular
toxicity mediated by cisplatin (CP) in rats. Forty-nine rats were divided into 7 groups (n= 7); …

[PDF][PDF] Allicin and Lycopene Possesses a Protective Effect against Methotrexate-induced Testicular Toxicity in Rats.

M Aboubakr, M Elbadawy, SS Ibrahim… - Pakistan Veterinary …, 2023 - academia.edu
Methotrexate (MTX) is a chemotherapeutic medicine frequently used to treat various forms of
cancer. The objective of our research was to examine whether allicin (ALC) and lycopene …

[PDF][PDF] Ameliorating effect of lycopene and N-acetylcysteine against cisplatin-induced cardiac injury in rats

A Elsayed, A Elkomy, M Alkafafy, R Elkammar, SE Fadl… - Pak Vet J, 2022 - researchgate.net
Cisplatin (CP) is used to treat a wide range of tumors and kills cells (anti-neoplastic drug)
through different mechanisms, including, formation of reactive oxygen species (ROS), DNA …

Antioxidant and anti-inflammatory potential of spirulina and thymoquinone mitigate the methotrexate-induced neurotoxicity

A Behairy, A Elkomy, F Elsayed, MMS Gaballa… - Naunyn-schmiedeberg's …, 2024 - Springer
The objective of this study was to investigate whether the neurotoxic effects caused by
methotrexate (MTX), a frequently used chemotherapy drug, could be improved by …

Spirulina and thymoquinone protect against methotrexate-induced hepatic injury in rats

A Behairy, A Elkomy, F Elsayed, MMS Gaballa… - Revista Brasileira de …, 2024 - Springer
Methotrexate is a chemotherapy medication frequently used to treat various forms of cancer.
The purpose of this research was to examine if the administration of Arthrospira platensis …

Optimization of the Flavonoid Extraction Process from the Stem and Leaves of Epimedium Brevicornum and Its Effects on Cyclophosphamide-Induced Renal Injury

M Shi, H Pei, L Sun, W Chen, Y Zong, Y Zhao, R Du… - Molecules, 2023 - mdpi.com
Cyclophosphamide (CTX) is a broad-spectrum alkylated antitumor drug. It is clinically used
in the treatment of a variety of cancers, and renal toxicity is one of the adverse reactions after …

Mitigative potential of rhoifolin against cisplatin prompted testicular toxicity: biochemical, spermatogenic and histological based analysis

F Saher, MU Ijaz, A Hamza, QU Ain… - Toxicology …, 2023 - academic.oup.com
Rhoifolin (ROF) is a naturally occurring flavonoid compound with diverse pharmacological
and therapeutic benefits. The current investigation was designed to evaluate the curative …