Collagen changes in pelvic support tissues in women with pelvic organ prolapse

R Gong, Z Xia - European Journal of Obstetrics & Gynecology and …, 2019 - Elsevier
Pelvic organ prolapse is a group of diseases caused by weakened pelvic supportive tissue,
but the pathophysiology is not completely understood. Collagen is one of the most important …

Hydrogels for modified-release drug delivery systems

A Zielińska, P Eder, L Rannier… - Current …, 2022 - ingentaconnect.com
Hydrogels for the modified-release drug delivery systems are a continuously growing area of
interest for the pharmaceutical industry. According to the global market, the profit resulting …

[HTML][HTML] Injectable polyisocyanide hydrogel as healing supplement for connective tissue regeneration in an abdominal wound model

AN Gudde, MJJ van Velthoven, PHJ Kouwer… - Biomaterials, 2023 - Elsevier
In pelvic organ prolapse (POP) patients, the uterus, bladder and/or rectum descends into
vagina due to weakened support tissues. High recurrence rates after POP surgery suggest …

Polyisocyanides as a substrate to trigger vaginal fibroblast functioning in an in vitro model for prolapse repair

AN Gudde, MJJ van Velthoven, JPWR Roovers… - Biomaterials …, 2022 - Elsevier
Pelvic organ prolapse (POP) is the descent of the bladder, uterus, and/or rectum into the
vagina. POP is associated with altered vaginal fibroblast functionality and connective tissue …

The challenge of stress incontinence and pelvic organ prolapse: revisiting biologic mesh materials

W D'Angelo, J Dziki, SF Badylak - Current opinion in urology, 2019 - journals.lww.com
Clinical outcomes of surgical repair of POP/SUI are similar between biologic and synthetic
meshes, but biologic meshes have a lower incidence of adverse effects. Several strategies …

Effect of protease inhibitors in healing of the vaginal wall

M Florian-Rodriguez, K Chin, J Hamner, J Acevedo… - Scientific reports, 2019 - nature.com
Impaired elastogenesis and increased degradation of elastic fibers has been implicated in
the pathogenesis of pelvic organ prolapse. Loss of the elastogenic organizer, fibulin-5 …

Effective detection of biocatalysts with specified activity by using a hydrogel-based colourimetric assay–β-galactosidase case study

K Labus - PloS one, 2018 - journals.plos.org
The main aim of this study was to prepare gelatine-based hydrogels containing entrapped
substrate and to examine the applicability of these matrices for detection of enzymes with a …

Preparation of a novel injectable in situ-gelling nanoparticle with applications in controlled protein release and cancer cell entrapment

MK Khang, J Zhou, Y Huang, A Hakamivala, L Tang - RSC advances, 2018 - pubs.rsc.org
Temperature sensitive injectable hydrogels have been used as drug/protein carriers for a
variety of pharmaceutical applications. Oligo (ethylene glycol) methacrylate (OEGMA) …

Stop codon variant in EFEMP1 is associated with primary open-angle glaucoma due to impaired regulation of aqueous humor outflow

J Tan, S Cai, X Luo, Q Li, Y Chen, Z Chen… - Experimental Eye …, 2024 - Elsevier
It is known that the actin cytoskeleton and its associated cellular interactions in the
trabecular meshwork (TM) and juxtacanalicular tissues mainly contribute to the formation of …

[HTML][HTML] Gene expression features in patients with genital prolapse

MM Cheremin, TY Smolnova, AM Krasnyi… - Obstetrics and …, 2024 - bakhtiniada.ru
Genital prolapse is a serious problem affecting the female population due to its high
prevalence and absence of prerequisites to the decrease in its rate at the moment. Since the …