Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease
Cerebral blood flow (CBF) regulation is essential for normal brain function. The mammalian
brain has evolved a unique mechanism for CBF control known as neurovascular coupling …
brain has evolved a unique mechanism for CBF control known as neurovascular coupling …
Overcoming blood–brain barrier transport: Advances in nanoparticle-based drug delivery strategies
The blood–brain barrier (BBB), a unique structure in the central nervous system (CNS),
protects the brain from bloodborne pathogens by its excellent barrier properties …
protects the brain from bloodborne pathogens by its excellent barrier properties …
What is a pericyte?
Pericytes, spatially isolated contractile cells on capillaries, have been reported to control
cerebral blood flow physiologically, and to limit blood flow after ischaemia by constricting …
cerebral blood flow physiologically, and to limit blood flow after ischaemia by constricting …
Brain microvascular pericytes in vascular cognitive impairment and dementia
Pericytes are unique, multi-functional mural cells localized at the abluminal side of the
perivascular space in microvessels. Originally discovered in 19th century, pericytes had …
perivascular space in microvessels. Originally discovered in 19th century, pericytes had …
Capillary pericytes express α-smooth muscle actin, which requires prevention of filamentous-actin depolymerization for detection
L Alarcon-Martinez, S Yilmaz-Ozcan, M Yemisci… - elife, 2018 - elifesciences.org
Recent evidence suggests that capillary pericytes are contractile and play a crucial role in
the regulation of microcirculation. However, failure to detect components of the contractile …
the regulation of microcirculation. However, failure to detect components of the contractile …
Targeting pericytes for therapeutic approaches to neurological disorders
J Cheng, N Korte, R Nortley, H Sethi, Y Tang… - Acta …, 2018 - Springer
Many central nervous system diseases currently lack effective treatment and are often
associated with defects in microvascular function, including a failure to match the energy …
associated with defects in microvascular function, including a failure to match the energy …
The blood–brain barrier: an overview: structure, regulation, and clinical implications
P Ballabh, A Braun, M Nedergaard - Neurobiology of disease, 2004 - Elsevier
The blood–brain barrier (BBB) is a diffusion barrier, which impedes influx of most
compounds from blood to brain. Three cellular elements of the brain microvasculature …
compounds from blood to brain. Three cellular elements of the brain microvasculature …
Markers for human brain pericytes and smooth muscle cells
Brain pericytes and vascular smooth muscle cells (vSMCs) are a critical component of the
neurovascular unit and are important in regulating cerebral blood flow and blood-brain …
neurovascular unit and are important in regulating cerebral blood flow and blood-brain …
The blood-brain barrier/neurovascular unit in health and disease
BT Hawkins, TP Davis - Pharmacological reviews, 2005 - ASPET
The blood-brain barrier (BBB) is the regulated interface between the peripheral circulation
and the central nervous system (CNS). Although originally observed by Paul Ehrlich in 1885 …
and the central nervous system (CNS). Although originally observed by Paul Ehrlich in 1885 …
Pericyte contraction induced by oxidative-nitrative stress impairs capillary reflow despite successful opening of an occluded cerebral artery
Here we show that ischemia induces sustained contraction of pericytes on microvessels in
the intact mouse brain. Pericytes remain contracted despite successful reopening of the …
the intact mouse brain. Pericytes remain contracted despite successful reopening of the …