Positron emission tomography (PET) constitutes a functional imaging technique that is
harnessed to probe biological processes in vivo. PET imaging has been used to diagnose …

Immuno-positron emission tomography (immunoPET) is a paradigm-shifting molecular
imaging modality combining the superior targeting specificity of monoclonal antibody (mAb) …

Highlights•Nanobodies (Nbs) are camelid-derived single-domain antibodies.•Nbs have
powerful binding and inhibitory capacity with great therapeutic potential.•Nbs are used in …

In spite of the successful use of monoclonal antibodies (mAbs) in clinic for tumor treatment,
their applications are still hampered in therapeutic development due to limitations, such as …

Purpose The aim of the present paper is to review the role of HER2 antibodies, affibodies
and nanobodies as vehicles for imaging and therapy approaches in breast cancer, including …

Antibody fragments for which the sequence is available are suitable for straightforward
engineering and expression in both eukaryotic and prokaryotic systems. When produced as …

Imaging of expression of therapeutic targets may enable stratification of patients for targeted
treatments. The use of small radiolabeled probes based on the heavy-chain variable region …

Molecular imaging is paving the way towards noninvasive detection, staging, and treatment
follow-up of diseases such as cancer and inflammation-related conditions. Monoclonal …

Camelidae derived single-domain antibodies (sdAbs), commonly known as nanobodies
(Nbs), are the smallest antibody fragments with full antigen-binding capacity. Owing to their …

Highlights•Nanobodies are ideal candidates for molecular imaging.•A key variable
determining the in vivo performance of a nanobody-derived molecular imaging tracer is the …