[HTML][HTML] Radiochemistry for positron emission tomography
Positron emission tomography (PET) constitutes a functional imaging technique that is
harnessed to probe biological processes in vivo. PET imaging has been used to diagnose …
harnessed to probe biological processes in vivo. PET imaging has been used to diagnose …
ImmunoPET: concept, design, and applications
W Wei, ZT Rosenkrans, J Liu, G Huang, QY Luo… - Chemical …, 2020 - ACS Publications
Immuno-positron emission tomography (immunoPET) is a paradigm-shifting molecular
imaging modality combining the superior targeting specificity of monoclonal antibody (mAb) …
imaging modality combining the superior targeting specificity of monoclonal antibody (mAb) …
Nanobodies as therapeutics: big opportunities for small antibodies
S Steeland, RE Vandenbroucke, C Libert - Drug discovery today, 2016 - Elsevier
Highlights•Nanobodies (Nbs) are camelid-derived single-domain antibodies.•Nbs have
powerful binding and inhibitory capacity with great therapeutic potential.•Nbs are used in …
powerful binding and inhibitory capacity with great therapeutic potential.•Nbs are used in …
[PDF][PDF] Nanobody—A versatile tool for cancer diagnosis and therapeutics
M Liu, L Li, D Jin, Y Liu - Wiley Interdisciplinary Reviews …, 2021 - researchgate.net
In spite of the successful use of monoclonal antibodies (mAbs) in clinic for tumor treatment,
their applications are still hampered in therapeutic development due to limitations, such as …
their applications are still hampered in therapeutic development due to limitations, such as …
[HTML][HTML] HER2-directed antibodies, affibodies and nanobodies as drug-delivery vehicles in breast cancer with a specific focus on radioimmunotherapy and …
B Altunay, A Morgenroth, M Beheshti, A Vogg… - European journal of …, 2021 - Springer
Purpose The aim of the present paper is to review the role of HER2 antibodies, affibodies
and nanobodies as vehicles for imaging and therapy approaches in breast cancer, including …
and nanobodies as vehicles for imaging and therapy approaches in breast cancer, including …
Recombinant expression of nanobodies and nanobody-derived immunoreagents
A De Marco - Protein expression and purification, 2020 - Elsevier
Antibody fragments for which the sequence is available are suitable for straightforward
engineering and expression in both eukaryotic and prokaryotic systems. When produced as …
engineering and expression in both eukaryotic and prokaryotic systems. When produced as …
Same-day imaging using small proteins: clinical experience and translational prospects in oncology
Imaging of expression of therapeutic targets may enable stratification of patients for targeted
treatments. The use of small radiolabeled probes based on the heavy-chain variable region …
treatments. The use of small radiolabeled probes based on the heavy-chain variable region …
[HTML][HTML] Targeted nanobody-based molecular tracers for nuclear imaging and image-guided surgery
P Debie, N Devoogdt, S Hernot - Antibodies, 2019 - mdpi.com
Molecular imaging is paving the way towards noninvasive detection, staging, and treatment
follow-up of diseases such as cancer and inflammation-related conditions. Monoclonal …
follow-up of diseases such as cancer and inflammation-related conditions. Monoclonal …
Nanobodies as molecular imaging probes
Camelidae derived single-domain antibodies (sdAbs), commonly known as nanobodies
(Nbs), are the smallest antibody fragments with full antigen-binding capacity. Owing to their …
(Nbs), are the smallest antibody fragments with full antigen-binding capacity. Owing to their …
Engineering nanobodies for next-generation molecular imaging
E Yang, Q Liu, G Huang, J Liu, W Wei - Drug Discovery Today, 2022 - Elsevier
Highlights•Nanobodies are ideal candidates for molecular imaging.•A key variable
determining the in vivo performance of a nanobody-derived molecular imaging tracer is the …
determining the in vivo performance of a nanobody-derived molecular imaging tracer is the …