The Keap1‐Nrf2 system: a mediator between oxidative stress and aging
C Yu, JH Xiao - Oxidative Medicine and Cellular Longevity, 2021 - Wiley Online Library
Oxidative stress, a term that describes the imbalance between oxidants and antioxidants,
leads to the disruption of redox signals and causes molecular damage. Increased oxidative …
leads to the disruption of redox signals and causes molecular damage. Increased oxidative …
The AMPK pathway in fatty liver disease
C Fang, J Pan, N Qu, Y Lei, J Han, J Zhang… - Frontiers in …, 2022 - frontiersin.org
Lipid metabolism disorders are the primary causes for the occurrence and progression of
various liver diseases, including non-alcoholic fatty liver disease (NAFLD) and alcoholic fatty …
various liver diseases, including non-alcoholic fatty liver disease (NAFLD) and alcoholic fatty …
The Nrf2 pathway in liver diseases
J Zhou, Q Zheng, Z Chen - Frontiers in Cell and Developmental …, 2022 - frontiersin.org
Oxidative stress is the leading cause of most liver diseases, such as drug-induced liver
injury, viral hepatitis, and alcoholic hepatitis caused by drugs, viruses, and ethanol. The …
injury, viral hepatitis, and alcoholic hepatitis caused by drugs, viruses, and ethanol. The …
[HTML][HTML] AMPK and NRF2: Interactive players in the same team for cellular homeostasis?
E Petsouki, SNS Cabrera, EH Heiss - Free Radical Biology and Medicine, 2022 - Elsevier
NRF2 (Nuclear factor E2 p45‐related factor 2) is a stress responsive transcription factor
lending cells resilience against oxidative, xenobiotic, and also nutrient or proteotoxic insults …
lending cells resilience against oxidative, xenobiotic, and also nutrient or proteotoxic insults …
[HTML][HTML] Astragaloside IV mitigates cerebral ischaemia-reperfusion injury via inhibition of P62/Keap1/Nrf2 pathway-mediated ferroptosis
L Wang, C Liu, L Wang, B Tang - European journal of pharmacology, 2023 - Elsevier
Cerebral ischaemia-reperfusion injury (CIRI) is a critical component of ischaemic stroke
pathogenesis. Ferroptosis contributes to and aggravates CIRI, whereas the P62/Kelch-like …
pathogenesis. Ferroptosis contributes to and aggravates CIRI, whereas the P62/Kelch-like …
Roles of Nrf2 in liver diseases: molecular, pharmacological, and epigenetic aspects
M Galicia-Moreno, S Lucano-Landeros… - Antioxidants, 2020 - mdpi.com
Liver diseases represent a critical health problem with 2 million deaths worldwide per year,
mainly due to cirrhosis and its complications. Oxidative stress plays an important role in the …
mainly due to cirrhosis and its complications. Oxidative stress plays an important role in the …
[HTML][HTML] Protective effect of fucoidan against iron overload and ferroptosis-induced liver injury in rats exposed to alcohol
M Xue, Y Tian, Y Sui, H Zhao, H Gao, H Liang… - Biomedicine & …, 2022 - Elsevier
This study was aimed to explore the effects of fucoidan on iron overload and ferroptosis-
induced liver injury, and the underlying mechanisms in rats exposed to alcohol. Sprague …
induced liver injury, and the underlying mechanisms in rats exposed to alcohol. Sprague …
Dysfunction of autophagy in high-fat diet-induced non-alcoholic fatty liver disease
Q Ren, Q Sun, J Fu - Autophagy, 2024 - Taylor & Francis
Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases
with a global rising prevalence, which is closely associated with a high-fat diet (HFD) intake …
with a global rising prevalence, which is closely associated with a high-fat diet (HFD) intake …
[HTML][HTML] Decreased autophagosome biogenesis, reduced NRF2, and enhanced ferroptotic cell death are underlying molecular mechanisms of non-alcoholic fatty liver …
Background and aims Caloric excess and sedentary lifestyles have led to an epidemic of
obesity, metabolic syndrome, and non-alcoholic fatty liver disease (NAFLD). The objective of …
obesity, metabolic syndrome, and non-alcoholic fatty liver disease (NAFLD). The objective of …
4-Octyl itaconate attenuates LPS-induced acute kidney injury by activating Nrf2 and inhibiting STAT3 signaling
L Xu, J Cai, C Li, M Yang, T Duan, Q Zhao, Y Xi… - Molecular …, 2023 - Springer
Background Septic acute kidney injury (S-AKI) is the leading form of acute kidney failure
among hospitalized patients, and the inflammatory response is involved in this process. 4 …
among hospitalized patients, and the inflammatory response is involved in this process. 4 …