Genomic DNA is folded into loops and topologically associating domains (TADs), which
serve important structural and regulatory roles. It has been proposed that these genomic …

SMC (structural maintenance of chromosomes) protein complexes are an evolutionarily
conserved family of motor proteins that hold sister chromatids together and fold genomes …

Understanding structural dynamics of biomolecules at the single-molecule level is vital to
advancing our knowledge of molecular mechanisms. Currently, there are few techniques …

Structural maintenance of chromosomes (SMC) complexes are key organizers of
chromosome architecture in all kingdoms of life. Despite seemingly divergent functions, such …

Condensin plays crucial roles in chromosome organization and compaction, but the
mechanistic basis for its functions remains obscure. We used single-molecule imaging to …

Structural maintenance of chromosomes (SMC) complexes are essential for genome
organization from bacteria to humans, but their mechanisms of action remain poorly …

Protein complexes built of structural maintenance of chromosomes (SMC) and kleisin
subunits, including cohesin, condensin and the Smc5/6 complex, are master organizers of …

Complexes containing a pair of structural maintenance of chromosomes (SMC) family
proteins are fundamental for the three-dimensional (3D) organization of genomes in all …

Multi-subunit SMC complexes control chromosome superstructure and promote
chromosome disjunction, conceivably by actively translocating along DNA double helices …

The cohesin complex topologically encircles DNA to promote sister chromatid cohesion.
Alternatively, cohesin extrudes DNA loops, thought to reflect chromatin domain formation …