In Finland, the frequency of isolated cleft palate (CP) is higher than that of isolated cleft lip
with or without cleft palate (CL/P). This trend contrasts to that in other European countries but …

Non-syndromic orofacial clefts (NSOCs) are the most common craniofacial malformation. In
the complex aetiology and pathogenesis of NSOCs, genetic factors play a crucial role and …

The microenvironment of a cancer stem cell (CSC) niche is often found in coexistence with
cancer-associated fibroblasts (CAFs). Here, we show the first in-depth analysis of the …

Introduction The lips fulfill various critical physiological roles besides being viewed as a
fundamental aesthetic feature contributing to the perception of health and beauty. Therefore …

Interferon Regulatory Factor 6 (IRF6) and Grainyhead Like Transcription Factor 3 (GRHL3)
are transcription factors that orchestrate gene regulatory networks required for the balance …

Objectives Cell models have shown great promise as tools for research, potentially
providing intriguing alternatives to animal models. However, the original tissue …

Simple Summary Congenital abnormalities in animals are a major concern for breeders due
to the increased economic loss they entail. The aim of this article was to describe a …

In Finland the frequency of isolated cleft palate (CP) is higher than that of isolated cleft lip
with or without cleft palate (CL/P). This trend contrasts to that in other European countries but …

Objectives Considering limitations of previous studies and differences across populations
and subtypes, this study aimed to identify new potential SNPs around IRF6 associated with …

IRF6 is a key genetic determinant of syndromic and non-syndromic cleft lip and palate. The
ability to interrogate post-embryonic requirements of Irf6 has been hindered, as global Irf6 …