RIG-I-like receptors (RLRs) are intracellular pattern recognition receptors that detect viral or
bacterial infection and induce host innate immune responses. The RLRs family comprises …

Hepatocellular carcinoma (HCC) is a common malignancy, and the hepatitis B virus (HBV) is
its major pathogenic factor. Over the past decades, it has been confirmed that HBV infection …

Metabolic adaptation to viral infections critically determines the course and manifestations of
disease. At the systemic level, a significant feature of viral infection and inflammation that …

Background & Aims We aimed to assess the safety and immunogenicity of inactivated whole-
virion severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines in patients …

Activation of STING signaling in DCs promotes antitumor immunity. Aerobic glycolysis is a
metabolic hallmark of activated DCs, but how the glycolytic pathway intersects with STING …

MAVS is an adapter protein involved in RIG-I-like receptor (RLR) signaling in mitochondria,
peroxisomes, and mitochondria-associated ER membranes (MAMs). However, the role of …

Mitochondria are master regulators of metabolism and have emerged as key signalling
organelles of the innate immune system. Each mitochondrion harbours potent agonists of …

Lactate, the end product of glycolysis, efficiently functions as the carbon source, signaling
molecules and immune regulators. Lactylation, being regulated by lactate, has recently been …

Chronic hepatitis B virus (HBV) infection remains a major health burden worldwide for which
there is still no effective curative treatment. Interferon (IFN) consists of a group of cytokines …

African swine fever is one of the most serious viral diseases caused by African swine fever
virus (ASFV). The metabolic changes induced by ASFV infection remain unknown. Here …