The engagement of the B cell receptor (BcR) on the surface of leukemic cells represents a
key event in chronic lymphocytic leukemia (CLL) since it can lead to the maintenance and …

Chronic lymphocytic leukemia (CLL) is characterized by the existence of subsets of patients
with (quasi) identical, stereotyped B-cell receptor (BcR) immunoglobulins. Patients in certain …

Sequence convergence, otherwise stereotypy, of B-cell receptor immunoglobulin (BcR IG)
from unrelated patients is a distinctive feature of the IG gene repertoire in chronic …

Almost one-third of all patients with chronic lymphocytic leukemia (CLL) express stereotyped
B-cell receptor immunoglobulins (BcR IG) and can be assigned to distinct subsets, each with …

Even though SYK and ZAP70 kinases share high sequence homology and serve analogous
functions, their expression in B and T cells is strictly segregated throughout evolution. Here …

Chronic lymphocytic leukemia (CLL) patients with differential somatic hypermutation status
of the immunoglobulin heavy variable genes, namely mutated or unmutated, display …

BIRC3 is monoallelically deleted in up to 80% of chronic lymphocytic leukemia (CLL) cases
harboring del (11q). In addition, truncating mutations in the remaining allele of this gene can …

Subset# 201 is a clinically indolent subgroup of patients with chronic lymphocytic leukemia
defined by the expression of stereotyped, mutated IGHV4-34/IGLV1-44 BCR Ig. Subset# 201 …

Immunoglobulin (Ig) gene rearrangements and oncogenic translocations are routinely
assessed during the characterization of B cell neoplasms and stratification of patients with …

T-cell redirecting therapies (TCRTs), such as CAR-or TCR T-cells and T-cell engagers, have
emerged as a highly effective treatment modality, particularly in the B-and plasma cell …