Aging is a gradual and irreversible pathophysiological process. It presents with declines in
tissue and cell functions and significant increases in the risks of various aging-related …

Senescence compromises the essential role that the endothelium plays in maintaining
vascular homeostasis, so promoting endothelial dysfunction and the development of age …

Aging is a prominent risk factor for cardiovascular diseases, which is the leading cause of
death around the world. Recently, cellular senescence has received potential attention as a …

Accumulating evidence indicates gut microbiota contributes to aging-related disorders.
However, the exact mechanism underlying gut dysbiosis-related pathophysiological …

Despite encouraging progresses in the development of novel therapies, cancer remains the
dominant cause of disease-related mortality and has become a leading economic and …

Hutchinson–Gilford progeria syndrome (HGPS) is a rare, autosomal-dominant, and fatal
premature aging syndrome. HGPS is most often derived from a de novo point mutation in the …

Glucagon-like peptide-1 receptor agonists (GLP1RA) have been transformative for patients
and clinicians in treating type-2 diabetes and obesity. Drugs of this class, the bioavailability …

Abstract Aims Hutchinson–Gilford progeria syndrome (HGPS) is a pre-mature aging disorder
caused by the mutation of the LMNA gene leading to an irreversibly farnesylated lamin A …

In humans, aging is characterized by a gradual decline of physical and psychological
functions, with the concomitant onset of chronic-degenerative diseases, which ultimately …

Simple Summary Age-related cardiovascular disease is the foremost cause of death
globally. Despite medical advances, we have been unable to stop or reverse the underlying …