Chemoresistance has been a significant problem affecting the efficacy of drugs targeting
tumors for decades. MGMT, known as O6-methylguanine-DNA methyltransferase, is a DNA …

We have extended our understanding of the molecular biology that underlies adult
glioblastoma over many years. By contrast, high-grade gliomas in children and adolescents …

The DNA repair protein O 6-methylguanine DNA methyltransferase (MGMT) removes alkyl
adducts from the O 6 position of guanine. MGMT expression is decreased in some tumor …

Neoplastic cells simultaneously harbor widespread genomic hypomethylation, more
regional areas of hypermethylation, and increased DNA-methyltransferase (DNA-MTase) …

The evolutionary history of tumor cell populations can be reconstructed from patterns of
genetic alterations. In contrast to stable genetic events, epigenetic states are reversible and …

O6-methylguanine-DNA methyltransferase (MGMT) plays a crucial role in the defense
against alkylating agents that generate, among other lesions, O6-alkylguanine in DNA …

Temozolomide (TMZ)-based therapy is the standard of care for patients with glioblastoma
multiforme (GBM), and resistance to this drug in GBM is modulated by the DNA repair …

DNA methylation is not just for basic scientists any more. There is a growing awareness in
the medical field that having the correct pattern of genomic methylation is essential for …

Background: Sporadic colorectal cancers often arise from a region of cells characterized by
a “field defect” that has not been well defined molecularly. DNA methylation has been …

O6-Methylguanine-DNA methyltransferase (MGMT) is a suicide enzyme that repairs the pre-
mutagenic, pre-carcinogenic and pre-toxic DNA damage O6-methylguanine. It also repairs …