Aberrant signalling of ERBB family members plays an important role in tumorigenesis and in
the escape from antitumour immunity in multiple malignancies. Molecular-targeted agents …

Receptor tyrosine kinases (RTKs) play an important role in a variety of cellular processes
including growth, motility, differentiation, and metabolism. As such, dysregulation of RTK …

The HER3 protein, that belongs to the ErbB/HER receptor tyrosine kinase (RTK) family, is
expressed in several types of tumors. That fact, together with the role of HER3 in promoting …

The ErbB receptor tyrosine kinases play important roles in normal physiology and in cancer.
Epidermal growth factor receptor (EGFR) and ErbB2 in particular are mutated in many …

The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase receptor that is
frequently expressed in epithelial tumors. The EGFR was the first receptor to be proposed as …

Some non–small cell lung cancers (NSCLCs) harbor a single specific mutated oncogene
that is thought to be the primary genetic “driver” leading to cancer. The two most commonly …

Background Somatic mutations of the k-RAS oncogene have been assessed as a
mechanism of de-novo resistance to epidermal growth factor receptor (EGFR) tyrosine …

Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors gefitinib and erlotinib are
effective therapies for non–small cell lung cancer patients whose tumors harbor somatic …

The epidermal growth factor receptor (EGFR) is a central regulator of proliferation and
progression in human cancers. Five EGFR inhibitors, two monoclonal antibodies and three …

Somatic mutations in exons encoding the tyrosine kinase domain of the epidermal growth
factor receptor (EGFR) gene are found in human lung adenocarcinomas and are associated …