Antitumour immunity regulated by aberrant ERBB family signalling
S Kumagai, S Koyama, H Nishikawa - Nature Reviews Cancer, 2021 - nature.com
Aberrant signalling of ERBB family members plays an important role in tumorigenesis and in
the escape from antitumour immunity in multiple malignancies. Molecular-targeted agents …
the escape from antitumour immunity in multiple malignancies. Molecular-targeted agents …
Mechanisms of receptor tyrosine kinase activation in cancer
Receptor tyrosine kinases (RTKs) play an important role in a variety of cellular processes
including growth, motility, differentiation, and metabolism. As such, dysregulation of RTK …
including growth, motility, differentiation, and metabolism. As such, dysregulation of RTK …
HER3 in cancer: from the bench to the bedside
L Gandullo-Sánchez, A Ocaña, A Pandiella - Journal of Experimental & …, 2022 - Springer
The HER3 protein, that belongs to the ErbB/HER receptor tyrosine kinase (RTK) family, is
expressed in several types of tumors. That fact, together with the role of HER3 in promoting …
expressed in several types of tumors. That fact, together with the role of HER3 in promoting …
ErbB receptors and signaling pathways in cancer
NE Hynes, G MacDonald - Current opinion in cell biology, 2009 - Elsevier
The ErbB receptor tyrosine kinases play important roles in normal physiology and in cancer.
Epidermal growth factor receptor (EGFR) and ErbB2 in particular are mutated in many …
Epidermal growth factor receptor (EGFR) and ErbB2 in particular are mutated in many …
The epidermal growth factor receptor pathway: a model for targeted therapy
M Scaltriti, J Baselga - Clinical cancer research, 2006 - AACR
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase receptor that is
frequently expressed in epithelial tumors. The EGFR was the first receptor to be proposed as …
frequently expressed in epithelial tumors. The EGFR was the first receptor to be proposed as …
KRAS Mutations in Non–Small Cell Lung Cancer
Some non–small cell lung cancers (NSCLCs) harbor a single specific mutated oncogene
that is thought to be the primary genetic “driver” leading to cancer. The two most commonly …
that is thought to be the primary genetic “driver” leading to cancer. The two most commonly …
Assessment of somatic k-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents: a systematic review and meta-analysis of studies in …
H Linardou, IJ Dahabreh, D Kanaloupiti… - The lancet …, 2008 - thelancet.com
Background Somatic mutations of the k-RAS oncogene have been assessed as a
mechanism of de-novo resistance to epidermal growth factor receptor (EGFR) tyrosine …
mechanism of de-novo resistance to epidermal growth factor receptor (EGFR) tyrosine …
Mechanisms of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non–small cell lung cancer
JA Engelman, PA Jänne - Clinical Cancer Research, 2008 - AACR
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors gefitinib and erlotinib are
effective therapies for non–small cell lung cancer patients whose tumors harbor somatic …
effective therapies for non–small cell lung cancer patients whose tumors harbor somatic …
Mechanisms of acquired resistance to cetuximab: role of HER (ErbB) family members
DL Wheeler, S Huang, TJ Kruser, MM Nechrebecki… - Oncogene, 2008 - nature.com
The epidermal growth factor receptor (EGFR) is a central regulator of proliferation and
progression in human cancers. Five EGFR inhibitors, two monoclonal antibodies and three …
progression in human cancers. Five EGFR inhibitors, two monoclonal antibodies and three …
Lung adenocarcinomas induced in mice by mutant EGF receptors foundin human lung cancers respondto a tyrosine kinase inhibitor orto down-regulation of the …
K Politi, MF Zakowski, PD Fan… - Genes & …, 2006 - genesdev.cshlp.org
Somatic mutations in exons encoding the tyrosine kinase domain of the epidermal growth
factor receptor (EGFR) gene are found in human lung adenocarcinomas and are associated …
factor receptor (EGFR) gene are found in human lung adenocarcinomas and are associated …