The serine/threonine kinase glycogen synthase kinase-3 (GSK-3) was initially identified and
studied in the regulation of glycogen synthesis. GSK-3 functions in a wide range of cellular …

The mammalian target of rapamycin (mTOR) senses nutrients and growth factors to
coordinate cell growth, metabolism and autophagy. Extensive research has mapped the …

Haematopoietic stem cells (HSCs) are a rare cell type that reconstitute the entire blood and
immune systems after transplantation and can be used as a curative cell therapy for a variety …

The ability to expand hematopoietic stem and progenitor cells (HSPCs) ex vivo is critical to
fully realize the potential of HSPC-based therapies. In particular, the application of clinically …

Immune system defects are at the center of aging and a range of diseases. Here, we show
that prolonged fasting reduces circulating IGF-1 levels and PKA activity in various cell …

Maintaining proteostasis is key to resisting stress and promoting healthy aging. Proteostasis
is necessary to preserve stem cell function, but little is known about the mechanisms that …

Many aspects of cellular physiology remain unstudied in somatic stem cells, for example,
there are almost no data on protein synthesis in any somatic stem cell. Here we set out to …

Radiation therapy induces DNA damage and inflammation leading to fibrosis. Fibrosis can
occur 4 to 12 months after radiation therapy. This process worsens with time and years …

Lithium salts have been in the therapeutic toolbox for better or worse since the 19th century,
with purported benefit in gout, hangover, insomnia, and early suggestions that lithium …

The hematopoietic system produces new blood cells throughout life. Mature blood cells all
derived from a pool of rare long-lived hematopoietic stem cells (HSCs) that are mostly …