As a predominant type II protein arginine methyltransferase, PRMT5 plays critical roles in
various normal cellular processes by catalyzing the mono-and symmetrical dimethylation of …

Arginine methylation governs important cellular processes that impact growth and
proliferation, as well as differentiation and development. Through their ability to catalyze …

Protein arginine methyltransferase 5 (PRMT5) is a type II arginine methyltransferase that
catalyzes the formation of symmetric dimethylarginine in a number of nuclear and …

AKT is involved in a number of key cellular processes including cell proliferation, apoptosis
and metabolism. Hyperactivation of AKT is associated with many pathological conditions …

ATR responds to mechanical stress at the nuclear envelope and mediates envelope-
associated repair of aberrant topological DNA states. By combining microscopy, electron …

Protein arginine methyltransferases (PRMTs) are known for their ability to catalyze
methylation of specific arginine residues in a wide variety of cellular proteins, which are …

Imatinib-insensitive leukemia stem cells (LSCs) are believed to be responsible for resistance
to BCR-ABL tyrosine kinase inhibitors and relapse of chronic myelogenous leukemia (CML) …

The Golgi apparatus is a central intracellular membrane-bound organelle with key functions
in trafficking, processing, and sorting of newly synthesized membrane and secretory proteins …

Primary microcephaly 1 is a neurodevelopmental disorder caused by mutations in the
MCPH1 gene, whose product MCPH1 (also known as microcephalin and BRIT1) regulates …

Increasing evidence suggests that PRMT 5, a protein arginine methyltransferase, is involved
in tumorigenesis. However, no systematic research has demonstrated the cell‐transforming …