An overview of coumarin as a versatile and readily accessible scaffold with broad-ranging biological activities
F Annunziata, C Pinna, S Dallavalle… - International Journal of …, 2020 - mdpi.com
Privileged structures have been widely used as an effective template for the research and
discovery of high value chemicals. Coumarin is a simple scaffold widespread in Nature and …
discovery of high value chemicals. Coumarin is a simple scaffold widespread in Nature and …
Synthetic and natural coumarins as potent anticonvulsant agents: A review with structure–activity relationship
RS Keri, S Budagumpi… - Journal of Clinical …, 2022 - Wiley Online Library
What is known and objective The main objective of this review is to highlight the most
relevant studies since 1990 (to date) in the area of medicinal chemistry aspects to provide a …
relevant studies since 1990 (to date) in the area of medicinal chemistry aspects to provide a …
Antiviral Activity of Isoimperatorin Against Influenza A Virus in vitro and its Inhibition of Neuraminidase
Y Lai, T Han, S Zhan, Y Jiang, X Liu, G Li - Frontiers in Pharmacology, 2021 - frontiersin.org
Influenza A virus (IAV) poses a severe threat to human health and is a major public health
problem worldwide. As global anti-influenza virus drug resistance has increased …
problem worldwide. As global anti-influenza virus drug resistance has increased …
[HTML][HTML] Therapeutic potential of 4-substituted coumarins: A conspectus
Substituted coumarins are a very large family of naturally occurring compounds, and
substituted coumarins are versatile scaffolds for the development of medicinally active …
substituted coumarins are versatile scaffolds for the development of medicinally active …
A review on the synthesis and applications of molecules as anticonvulsant drug agent candidates
O Özbek, MB Gürdere - Medicinal Chemistry Research, 2020 - Springer
Epilepsy is one of the most common neurological disorders worldwide and it requires a long-
term or life-long treatment. Current standard treatment includes the use of antiepileptic …
term or life-long treatment. Current standard treatment includes the use of antiepileptic …
Exploring new cyclohexane carboxamides based GABA agonist: Design, synthesis, biological evaluation, in silico ADME and docking studies
WH Abd-Allah, MAEM Anwar, ER Mohammed… - Bioorganic …, 2023 - Elsevier
The new series of 5a-e, 6a-e and 7a-e derivatives were designed, synthesized and tested
for their anticonvulsant activity using “gold standard methods” ScPTZ and MES model …
for their anticonvulsant activity using “gold standard methods” ScPTZ and MES model …
Anticonvulsant Classes and Possible Mechanism of Actions
WH Abd-Allah, MA El-Mohsen Anwar… - ACS Chemical …, 2023 - ACS Publications
Epilepsy is considered one of the most common neurological disorders worldwide; it needs
long-term or life-long treatment. Despite the presence of several novel antiepileptic drugs …
long-term or life-long treatment. Despite the presence of several novel antiepileptic drugs …
Design and synthesis of novel cycloalkanecarboxamide parabanic acid hybrids as anticonvulsants
WH Abd-Allah, MS Abd El-Maksoud… - Medicinal Chemistry …, 2024 - Springer
Aiming to develop novel anticonvulsant agents a new series of novel
cycloalkanecarboxamide parabanic acid hybrids series 8, 9 and 10 possessing the essential …
cycloalkanecarboxamide parabanic acid hybrids series 8, 9 and 10 possessing the essential …
New frontier radioiodinated probe based on in silico resveratrol repositioning for microtubules dynamic targeting
AF Mahmoud, MH Aboumanei… - … Journal of Radiation …, 2023 - Taylor & Francis
Purpose As the 'de novo'drug discovery faces a highly attrition rates, drug repositioning
procures a heighten concern in identifying novel uses for existing medications. This study …
procures a heighten concern in identifying novel uses for existing medications. This study …
Design, synthesis, biological evaluation, and computational studies of novel thiazolo-pyrazole hybrids as promising selective COX-2 inhibitors: Implementation of …
AA Marzouk, ES Taher, MSA Shaykoon, P Lan… - Bioorganic …, 2021 - Elsevier
A novel series of thiazolo-pyrazole hybrids has been prepared and assessed for their in vitro
COX-1/COX-2 inhibitory activity. Compound 6c exhibited the most selective COX-2 inhibition …
COX-1/COX-2 inhibitory activity. Compound 6c exhibited the most selective COX-2 inhibition …