Privileged structures have been widely used as an effective template for the research and
discovery of high value chemicals. Coumarin is a simple scaffold widespread in Nature and …

What is known and objective The main objective of this review is to highlight the most
relevant studies since 1990 (to date) in the area of medicinal chemistry aspects to provide a …

Influenza A virus (IAV) poses a severe threat to human health and is a major public health
problem worldwide. As global anti-influenza virus drug resistance has increased …

Substituted coumarins are a very large family of naturally occurring compounds, and
substituted coumarins are versatile scaffolds for the development of medicinally active …

Epilepsy is one of the most common neurological disorders worldwide and it requires a long-
term or life-long treatment. Current standard treatment includes the use of antiepileptic …

The new series of 5a-e, 6a-e and 7a-e derivatives were designed, synthesized and tested
for their anticonvulsant activity using “gold standard methods” ScPTZ and MES model …

Epilepsy is considered one of the most common neurological disorders worldwide; it needs
long-term or life-long treatment. Despite the presence of several novel antiepileptic drugs …

Aiming to develop novel anticonvulsant agents a new series of novel
cycloalkanecarboxamide parabanic acid hybrids series 8, 9 and 10 possessing the essential …

Purpose As the 'de novo'drug discovery faces a highly attrition rates, drug repositioning
procures a heighten concern in identifying novel uses for existing medications. This study …

A novel series of thiazolo-pyrazole hybrids has been prepared and assessed for their in vitro
COX-1/COX-2 inhibitory activity. Compound 6c exhibited the most selective COX-2 inhibition …