Age is a major risk factor for cancer, but how aging impacts tumor control remains unclear. In
this study, we establish that aging of the immune system, regardless of the age of the stroma …

Hematopoiesis can occur outside of the bone marrow during inflammatory stress to increase
the production of primarily myeloid cells at extramedullary sites; this process is known as …

Immunotherapy, especially immune checkpoint blockade therapy, represents a major
milestone in the history of cancer therapy. However, the current response rate to …

Chromatin priming promotes cell-type-specific gene expression, lineage differentiation, and
development. The mechanism of chromatin priming has not been fully understood. Here, we …

Neutrophils are traditionally viewed as uncomplicated exterminators that arrive quickly at
sites of infection, kill pathogens, and then expire. However, recent studies employing …

Tumor-associated macrophages exhibit high heterogeneity and contribute to the
establishment of an immunosuppressive tumor microenvironment (TME). Although …

Tumors protect themselves from immune clearance by promoting extramedullary
hematopoiesis. A new study in PLOS Biology provides insights into the mechanisms …