Candida albicans cell-type switching and functional plasticity in the mammalian host

SM Noble, BA Gianetti, JN Witchley - Nature Reviews Microbiology, 2017 - nature.com
Candida albicans is a ubiquitous commensal of the mammalian microbiome and the most
prevalent fungal pathogen of humans. A cell-type transition between yeast and hyphal …

The spectrum of fungi that infects humans

JR Köhler, A Casadevall… - Cold Spring …, 2015 - perspectivesinmedicine.cshlp.org
Few among the millions of fungal species fulfill four basic conditions necessary to infect
humans: high temperature tolerance, ability to invade the human host, lysis and absorption …

Passage through the mammalian gut triggers a phenotypic switch that promotes Candida albicans commensalism

K Pande, C Chen, SM Noble - Nature genetics, 2013 - nature.com
Abstract Among∼ 5,000,000 fungal species, C. albicans is exceptional in its lifelong
association with humans, either within the gastrointestinal microbiome or as an invasive …

Sexual reproduction and the evolution of microbial pathogens

J Heitman - Current Biology, 2006 - cell.com
Three common systemic human fungal pathogens—Cryptococcus neoformans, Candida
albicans and Aspergillus fumigatus—have retained all the machinery to engage in sexual …

White-Opaque Switching in Natural MTLa/α Isolates of Candida albicans: Evolutionary Implications for Roles in Host Adaptation, Pathogenesis, and Sex

J Xie, L Tao, CJ Nobile, Y Tong, G Guan, Y Sun… - PLoS …, 2013 - journals.plos.org
Phenotypic transitions play critical roles in host adaptation, virulence, and sexual
reproduction in pathogenic fungi. A minority of natural isolates of Candida albicans, which …

Parallels in fungal pathogenesis on plant and animal hosts

AC Sexton, BJ Howlett - Eukaryotic cell, 2006 - Am Soc Microbiol
Fungi are important pathogens of plants and cause more significant yield losses than
bacteria or viruses. However, bacteria and viruses are more important than fungi as …

Property Differences among the Four Major Candida albicans Strain Clades

DM MacCallum, L Castillo, K Nather, CA Munro… - Eukaryotic …, 2009 - Am Soc Microbiol
ABSTRACT A selection of 43 Candida albicans isolates, chosen to represent the four major
strain clades of the species and also intraclade diversity, was screened for their virulence in …

Candida albicans Strain Maintenance, Replacement, and Microvariation Demonstrated by Multilocus Sequence Typing

FC Odds, AD Davidson, MD Jacobsen… - Journal of clinical …, 2006 - Am Soc Microbiol
We typed 165 Candida albicans isolates from 44 different sources by multilocus sequence
typing (MLST) and ABC typing of rRNA genes and determined their homozygosity or …

Candida albicans isolates 529L and CHN1 exhibit stable colonization of the murine gastrointestinal tract

LD McDonough, AA Mishra, N Tosini, P Kakade… - Mbio, 2021 - Am Soc Microbiol
Candida albicans is a pathobiont that colonizes multiple niches in the body including the
gastrointestinal (GI) tract but is also responsible for both mucosal and systemic infections …

Sex and virulence of human pathogenic fungi

K Nielsen, J Heitman - Advances in genetics, 2007 - Elsevier
Over the past decade, opportunistic fungal infectious diseases have increased in prevalence
as the population of immunocompromised individuals escalated due to HIV/AIDS and …