Angiogenesis, the formation of new blood vessels, is a complex and dynamic process
regulated by various pro-and anti-angiogenic molecules, which plays a crucial role in tumor …

Primary lung cancer is one of the most common malignant tumors in China. Approximately
60% of lung cancer patients have distant metastasis at the initial diagnosis, so it is …

We conducted the Reproducibility Project: Cancer Biology to investigate the replicability of
preclinical research in cancer biology. The initial aim of the project was to repeat 193 …

Abstract Background Cancer stem cells (CSCs) are subpopulations of cancer cells sharing
similar characteristics as normal stem or progenitor cells such as self-renewal ability and …

Following a diagnosis of breast cancer, the most immediate challenges in patient
management are the determination of prognosis and identification of the most appropriate …

Abstract Exosomes are 40–100 nm nano-sized vesicles that are released from many cell
types into the extracellular space. Such vesicles are widely distributed in various body fluids …

Exosomes (Exo) hold great promise as endogenous nanocarriers that can deliver biological
information between cells. However, Exo are limited in terms of their abilities to target …

The emergence of microRNAs has been one of the defining developments in cancer biology
over the past decade, and the explosion of knowledge in this area has brought forward new …

Upon exposure to stress, tRNAs are enzymatically cleaved, yielding distinct classes of tRNA-
derived fragments (tRFs). We identify a novel class of tRFs derived from tRNA Glu, tRNA …

The first cancer-targeted microRNA (miRNA) drug—MRX34, a liposome-based miR-34
mimic—entered Phase I clinical trials in patients with advanced hepatocellular carcinoma in …