[HTML][HTML] Epigenetics-mediated pathological alternations and their potential in antiphospholipid syndrome diagnosis and therapy
Y Tan, Q Liu, Z Li, S Yang, L Cui - Autoimmunity reviews, 2022 - Elsevier
APS (antiphospholipid syndrome) is a systematic autoimmune disease accompanied with
venous or arterial thrombosis and poor pregnant manifestations, partly attributing to the …
venous or arterial thrombosis and poor pregnant manifestations, partly attributing to the …
Purine/purine isoster based scaffolds as new derivatives of benzamide class of HDAC inhibitors
This study reports the design, synthesis and evaluation of a series of histone deacetylase
(HDAC) inhibitors containing purine/purine isoster as a capping group and an N-(2 …
(HDAC) inhibitors containing purine/purine isoster as a capping group and an N-(2 …
Beta-tocotrienol exhibits more cytotoxic effects than gamma-tocotrienol on breast cancer cells by promoting apoptosis via a P53-independent PI3-kinase dependent …
Studies on tocotrienols have progressively revealed the benefits of these vitamin E isoforms
on human health. Beta-tocotrienol (beta-T3) is known to be less available in nature …
on human health. Beta-tocotrienol (beta-T3) is known to be less available in nature …
[HTML][HTML] Decitabine and all-trans retinoic acid synergistically exhibit cytotoxicity against elderly AML patients via miR-34a/MYCN axis
Y Cao, Y Liu, L Shang, W Wei, Y Shen, Q Gu… - Biomedicine & …, 2020 - Elsevier
This study aimed to investigate the efficacy and mechanism of decitabine (DAC) and all-
trans retinoic acid (ATRA) in elderly acute myeloid leukemia (AML) patients and cultured …
trans retinoic acid (ATRA) in elderly acute myeloid leukemia (AML) patients and cultured …
[HTML][HTML] Epigenetic therapy with chidamide alone or combined with 5‑azacitidine exerts antitumour effects on acute myeloid leukaemia cells in vitro
Z Li, J Zhang, M Zhou, JL Li, QC Qiu… - Oncology …, 2022 - spandidos-publications.com
Chidamide, a selective histone deacetylase inhibitor, has antitumour effects. 5‑azacitidine (5‑
AZA), a hypomethylating agent, is effective in treating acute myeloid leukaemia (AML) and …
AZA), a hypomethylating agent, is effective in treating acute myeloid leukaemia (AML) and …
Deciphering the role of histone modifications in uterine leiomyoma: acetylation of H3K27 regulates the expression of genes involved in proliferation, cell signaling, cell …
MC Carbajo-García, L de Miguel-Gómez… - Biomedicines, 2022 - mdpi.com
Uterine leiomyoma (UL) is a benign tumor arising from myometrium (MM) with a high
prevalence and unclear pathology. Histone modifications are altered in tumors, particularly …
prevalence and unclear pathology. Histone modifications are altered in tumors, particularly …
Enhanced cytotoxic effects in human oral squamous cell carcinoma cells treated with combined methyltransferase inhibitors and histone deacetylase inhibitors
R Ushio, M Hiroi, A Matsumoto, K Mori, N Yamamoto… - Biomedicines, 2022 - mdpi.com
Combined treatment of human oral squamous cell carcinoma (OSCCs) with DNA
methyltransferase inhibitors (DNMTis), histone methyltransferase inhibitors (HMTis), and …
methyltransferase inhibitors (DNMTis), histone methyltransferase inhibitors (HMTis), and …
Improved HDAC inhibition, stronger cytotoxic effect and higher selectivity against leukemias and lymphomas of novel, tricyclic vorinostat analogues
B Bieszczad, D Garbicz, M Świtalska, MK Dudek… - Pharmaceuticals, 2021 - mdpi.com
Histone deacetylase (HDAC) inhibitors are a class of drugs used in the cancer treatment.
Here, we developed a library of 19 analogues of Vorinostat, an HDAC inhibitor used in …
Here, we developed a library of 19 analogues of Vorinostat, an HDAC inhibitor used in …
[HTML][HTML] Histone deacetylase inhibition by suberoylanilide hydroxamic acid: a therapeutic approach to treat human uterine leiomyoma
MC Carbajo-García, Z García-Alcázar, A Corachán… - Fertility and …, 2022 - Elsevier
Objective To evaluate the effect of inhibition of histone deacetylases (HDACs) by
suberoylanilide hydroxamic acid (SAHA) treatment of human uterine leiomyoma primary …
suberoylanilide hydroxamic acid (SAHA) treatment of human uterine leiomyoma primary …
8a, a new acridine antiproliferative and pro-apoptotic agent targeting HDAC1/DNMT1
Q Zhang, Z Wang, X Chen, H Qiu, Y Gu… - International Journal of …, 2021 - mdpi.com
Epigenetic therapy using histone deacetylase (HDAC) inhibitors has become an attractive
project in new drug development. However, DNA methylation and histone acetylation are …
project in new drug development. However, DNA methylation and histone acetylation are …