The pathobiology of vascular dementia
C Iadecola - Neuron, 2013 - cell.com
Vascular cognitive impairment defines alterations in cognition, ranging from subtle deficits to
full-blown dementia, attributable to cerebrovascular causes. Often coexisting with …
full-blown dementia, attributable to cerebrovascular causes. Often coexisting with …
At the interface of sensory and motor dysfunctions and Alzheimer's disease
Recent evidence indicates that sensory and motor changes may precede the cognitive
symptoms of Alzheimer's disease (AD) by several years and may signify increased risk of …
symptoms of Alzheimer's disease (AD) by several years and may signify increased risk of …
Effect of exercise on brain health: the potential role of lactate as a myokine
It has been well established in epidemiological studies and randomized controlled trials that
habitual exercise is beneficial for brain health, such as cognition and mental health …
habitual exercise is beneficial for brain health, such as cognition and mental health …
Neurovascular coupling in the normal brain and in hypertension, stroke, and Alzheimer disease
H Girouard, C Iadecola - Journal of applied physiology, 2006 - journals.physiology.org
The brain is critically dependent on a continuous supply of blood to function. Therefore, the
cerebral vasculature is endowed with neurovascular control mechanisms that assure that …
cerebral vasculature is endowed with neurovascular control mechanisms that assure that …
Patterns of brain activation in people at risk for Alzheimer's disease
SY Bookheimer, MH Strojwas, MS Cohen… - New England journal …, 2000 - Mass Medical Soc
Background The ε 4 allele of the apolipoprotein E gene (APOE) is the chief known genetic
risk factor for Alzheimer's disease, the most common cause of dementia late in life. To …
risk factor for Alzheimer's disease, the most common cause of dementia late in life. To …
Structural insights into aberrant topological patterns of large-scale cortical networks in Alzheimer's disease
Recent research on Alzheimer's disease (AD) has shown that cognitive and memory decline
in this disease is accompanied by disrupted changes in the coordination of large-scale brain …
in this disease is accompanied by disrupted changes in the coordination of large-scale brain …
Multifunctional role of astrocytes as gatekeepers of neuronal energy supply
JL Stobart, CM Anderson - Frontiers in cellular neuroscience, 2013 - frontiersin.org
Dynamic adjustments to neuronal energy supply in response to synaptic activity are critical
for neuronal function. Glial cells known as astrocytes have processes that ensheath most …
for neuronal function. Glial cells known as astrocytes have processes that ensheath most …
Regional coherence changes in the early stages of Alzheimer's disease: a combined structural and resting-state functional MRI study
Recent functional imaging studies have indicated that the pathophysiology of Alzheimer's
disease (AD) can be associated with the changes in spontaneous low-frequency (< 0.08 Hz) …
disease (AD) can be associated with the changes in spontaneous low-frequency (< 0.08 Hz) …
The eye as a biomarker for Alzheimer's disease
Alzheimer's disease (AD) is a progressive neurodegenerative disorder resulting in dementia
and eventual death. It is the leading cause of dementia and the number of cases are …
and eventual death. It is the leading cause of dementia and the number of cases are …
SOD1 rescues cerebral endothelial dysfunction in mice overexpressing amyloid precursor protein
C Iadecola, F Zhang, K Niwa, C Eckman… - Nature …, 1999 - nature.com
Peptides derived from proteolytic processing of the β–amyloid precursor protein (APP),
including the amyloid–β peptide, are important for the pathogenesis of Alzheimer's …
including the amyloid–β peptide, are important for the pathogenesis of Alzheimer's …