Cell penetrating peptides: The potent multi-cargo intracellular carriers

K Kardani, A Milani, S H. Shabani… - Expert opinion on drug …, 2019 - Taylor & Francis
ABSTRACT Introduction: Cell penetrating peptides (CPPs) known as protein translocation
domains (PTD), membrane translocating sequences (MTS), or Trojan peptides (TP) are able …

The role of microRNA in the inflammatory response of wound healing

Y Jiang, X Xu, L Xiao, L Wang, S Qiang - Frontiers in Immunology, 2022 - frontiersin.org
Wound healing, a highly complex pathophysiological response to injury, includes four
overlapping phases of hemostasis, inflammation, proliferation, and remodeling. Initiation …

Emerging insights of peptide-based nanotherapeutics for effective management of rheumatoid arthritis

V Pathade, S Nene, S Ratnam, DK Khatri… - Life Sciences, 2023 - Elsevier
Rheumatoid arthritis (RA) is a chronic, prevalent, immune-mediated, inflammatory, joint
disorder affecting millions of people worldwide. Despite current treatment options, many …

Lauric acid ameliorates lipopolysaccharide (LPS)-induced liver inflammation by mediating TLR4/MyD88 pathway in Sprague Dawley (SD) rats

HU Khan, K Aamir, PR Jusuf, G Sethi, SP Sisinthy… - Life sciences, 2021 - Elsevier
Background Lipopolysaccharide (LPS) is an endotoxin that leads to inflammation in many
organs, including liver. It binds to pattern recognition receptors, that generally recognise …

Activation of Kupffer cells in NAFLD and NASH: Mechanisms and therapeutic interventions

GX Xu, S Wei, C Yu, SQ Zhao, WJ Yang… - Frontiers in Cell and …, 2023 - frontiersin.org
Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are
emerging as the leading causes of liver disease worldwide. These conditions can lead to …

TLR9: a friend or a foe

MM Saber, N Monir, AS Awad, ME Elsherbiny, HF Zaki - Life Sciences, 2022 - Elsevier
The innate immune system is a primary protective line in our body. It confers its protection
through different pattern recognition receptors (PRRs), especially toll like receptors (TLRs) …

Partial replacement of dietary fat with krill oil or coconut oil alleviates dyslipidemia by partly modulating lipid metabolism in lipopolysaccharide-injected rats on a high …

HK Son, BH Kim, J Lee, S Park, CB Oh, S Jung… - International Journal of …, 2022 - mdpi.com
This study investigated the effects of partial replacement of dietary fat with krill oil (KO) or
coconut oil (CO) on dyslipidemia and lipid metabolism in rats fed with a high-fat diet (HFD) …

Toll-like receptor signaling inhibitory peptide improves inflammation in animal model and human systemic lupus erythematosus

WY Baek, YS Choi, SW Lee, IO Son, KW Jeon… - International Journal of …, 2021 - mdpi.com
Toll-like receptors (TLRs) play a major role in the innate immune system. Several studies
have shown the regulatory effects of TLR-mediated pathways on immune and inflammatory …

A peptide derived from the core β-sheet region of TIRAP decoys TLR4 and reduces inflammatory and autoimmune symptoms in murine models

A Achek, HK Kwon, MC Patra, M Shah, R Hong… - …, 2020 - thelancet.com
Background TLRs are some of the actively pursued drug-targets in immune disorders.
Owing to a recent surge in the cognizance of TLR structural biology and signalling …

Electroacupuncture Alleviates Pain Responses and Inflammation in Collagen‐Induced Arthritis Rats via Suppressing the TLR2/4‐MyD88‐NF‐κB Signaling Pathway

SY Sun, QQ Yan, LN Qiao, YN Shi… - Evidence‐Based …, 2023 - Wiley Online Library
Background and Purpose. Electroacupuncture (EA) is effective on rheumatoid arthritis (RA),
an autoimmune disease, but the mechanisms involved remain poorly understood. This study …