Recent applications of immunomodulatory biomaterials for disease immunotherapy

H Dai, Q Fan, C Wang - Exploration, 2022 - Wiley Online Library
Immunotherapy is used to regulate systemic hyperactivation or hypoactivation to treat
various diseases. Biomaterial‐based immunotherapy systems can improve therapeutic …

The dark side of fibroblasts: cancer-associated fibroblasts as mediators of immunosuppression in the tumor microenvironment

L Monteran, N Erez - Frontiers in immunology, 2019 - frontiersin.org
Cancer-associated fibroblasts (CAFs) are prominent components of the microenvironment in
most types of solid tumors, and were shown to facilitate cancer progression by supporting …

Immune modulation by mesenchymal stem cells

W Jiang, J Xu - Cell proliferation, 2020 - Wiley Online Library
Mesenchymal stem cells (MSCs) can be derived from various adult tissues with multipotent
and self‐renewal abilities. The characteristics of presenting no major ethical concerns …

Immunomodulation by mesenchymal stem cells (MSCs): mechanisms of action of living, apoptotic, and dead MSCs

ARR Weiss, MH Dahlke - Frontiers in immunology, 2019 - frontiersin.org
Expectations on mesenchymal stem cell (MSC) treatment are high, especially in the fields of
sepsis, transplant medicine, and autoimmune diseases. Various pre-clinical studies have …

Biological functions of mesenchymal stem cells and clinical implications

A Naji, M Eitoku, B Favier, F Deschaseaux… - Cellular and Molecular …, 2019 - Springer
Mesenchymal stem cells (MSCs) are isolated from multiple biological tissues—adult bone
marrow and adipose tissues and neonatal tissues such as umbilical cord and placenta. In …

Mesenchymal stem cell immunomodulation: mechanisms and therapeutic potential

N Song, M Scholtemeijer, K Shah - Trends in pharmacological sciences, 2020 - cell.com
Mesenchymal stem/stromal cells (MSCs) are multipotent cells that are emerging as the most
promising means of allogeneic cell therapy. MSCs have inherent immunomodulatory …

Mesenchymal stem cell‐derived extracellular vesicles with high PD‐L1 expression for autoimmune diseases treatment

F Xu, Z Fei, H Dai, J Xu, Q Fan, S Shen… - Advanced …, 2022 - Wiley Online Library
Autoimmune diseases are the third most common disease influencing the quality of life of
many patients. Here, a programmed cell death‐ligand 1+(PD‐L1) mesenchymal stem cell …

Polymeric particle-based therapies for acute inflammatory diseases

ER Brannon, MV Guevara, NJ Pacifici, JK Lee… - Nature Reviews …, 2022 - nature.com
Acute inflammation is essential for initiating and coordinating the body's response to injuries
and infections. However, in acute inflammatory diseases, inflammation is not resolved but …

Mesenchymal stem cell secretome as an emerging cell-free alternative for improving wound repair

P Ahangar, SJ Mills, AJ Cowin - International journal of molecular …, 2020 - mdpi.com
The use of mesenchymal stem cells (MSC) for the treatment of cutaneous wounds is
currently of enormous interest. However, the broad translation of cell therapies into clinical …

3D bioprinting of heterogeneous constructs providing tissue‐specific microenvironment based on host–guest modulated dynamic hydrogel bioink for osteochondral …

W Dai, L Zhang, Y Yu, W Yan, F Zhao… - Advanced Functional …, 2022 - Wiley Online Library
Abstract 3D bioprinting is a promising strategy to develop heterogeneous constructs that
mimic osteochondral tissue. However, conventional bioprinted hydrogels suffer from …