Composite particles based on particle engineering for direct compaction

Z Li, X Lin, L Shen, YL Hong, Y Feng - International journal of …, 2017 - Elsevier
Direct compaction (DC) is the preferred method for tablet production. However, only a
minority of the active pharmaceutical ingredients (APIs) can be truly manufactured into …

Design, development and evaluation of aceclofenac and curcumin agglomerates by Crystallo Co-Agglomeration technique

V Malviya, S Manekar - Research Journal of Pharmacy and …, 2021 - indianjournals.com
Aceclofenac and Curcumin are both known to be used in joint pain or in the treatment of
rheumatoid arthritis, etc. But the problem arises in the bioavailability and absorption of these …

[HTML][HTML] Spherical crystallization: A technique use to reform solubility and flow property of active pharmaceutical ingredients

A Chatterjee, MM Gupta… - International journal of …, 2017 - ncbi.nlm.nih.gov
Tablets have been choice of manufacturers over the years due to their comparatively low
cost of manufacturing, packaging, shipping, and ease of administration; also have better …

Development of a resveratrol nanosuspension using the antisolvent precipitation method without solvent removal, based on a quality by design (QbD) approach

DH Kuk, ES Ha, DH Ha, WY Sim, SK Lee, JS Jeong… - Pharmaceutics, 2019 - mdpi.com
The purpose of this study was to develop a resveratrol nanosuspension with enhanced oral
bioavailability, based on an understanding of the formulation and process parameters of …

Nicotinamide-based agglomerates of ibuprofen: formulation, solid state characterization and evaluation of tableting performance with in-silico investigation

PH Sidwadkar, NH Salunkhe, KK Mali… - Future Journal of …, 2023 - Springer
Background The objective of the present investigation was to obtain directly compressible
agglomerates of ibuprofen with nicotinamide by a quasi-emulsification solvent diffusion …

Quality by design approach for oral bioavailability enhancement of irbesartan by self-nanoemulsifying tablets

J Patel, A Dhingani, K Garala, M Raval, N Sheth - Drug delivery, 2014 - Taylor & Francis
The present investigation was aimed to develop self-nanoemulsifying tablets (SNETs) as
novel nanosized solid oral dosage forms for Irbesartan (IRB). In the first part of the …

Particle Design of Drugs via Spherical Crystallization: A Review from Fundamental Aspects to Technology Development

M Sun, J Bi, Y Zhao, J Gong - Crystal Growth & Design, 2024 - ACS Publications
In the pharmaceutical industry, the production process of most active pharmaceutical
ingredients involves at least one crystallization step. Design of drug spheres via various …

Trace polymer coated clarithromycin spherulites: Formation mechanism, improvement in pharmaceutical properties and development of high-drug-loading direct …

X Zhang, M Su, W Meng, J Zhao, M Huang… - International Journal of …, 2024 - Elsevier
Clarithromycin (CLA) is a high dose antibiotic drug exhibiting poor flowability and
tabletability, making the tablet development challenging. This study aims to develop …

Design and development of docetaxel solid Self-Microemulsifying drug delivery system using principal component analysis and D-Optimal design

S Bhattacharya - Asian Journal of Pharmaceutics (AJP), 2018 - asiapharmaceutics.info
Aim: The aim of this research was to develop a solid self-emulsifying drug delivery system
for BCS Class IV drug (Docetaxel) using Principal component analysis (PCA) and D-Optimal …

[HTML][HTML] A new crystal engineering technique for dissolution enhancement of poorly soluble drugs combining quasi-emulsion and crystallo-co agglomeration methods

RR Makar, R Latif, EA Hosni… - Iranian Journal of …, 2020 - ncbi.nlm.nih.gov
A target of best dissolution improvement of poorly soluble drugs is a necessity for the
success of formulation in industry. The present work describes the preparation, optimization …