Unraveling the brain regulation of appetite: lessons from genetics
GSH Yeo, LK Heisler - Nature neuroscience, 2012 - nature.com
Over the past 20 years, genetic studies have illuminated critical pathways in the
hypothalamus and brainstem mediating energy homeostasis, such as the melanocortin …
hypothalamus and brainstem mediating energy homeostasis, such as the melanocortin …
Neurotrophic factor control of satiety and body weight
B Xu, X Xie - Nature Reviews Neuroscience, 2016 - nature.com
Energy balance—that is, the relationship between energy intake and energy expenditure—
is regulated by a complex interplay of hormones, brain circuits and peripheral tissues. Leptin …
is regulated by a complex interplay of hormones, brain circuits and peripheral tissues. Leptin …
The lighter side of BDNF
Brain-derived neurotrophic factor (BDNF) mediates energy metabolism and feeding
behavior. As a neurotrophin, BDNF promotes neuronal differentiation, survival during early …
behavior. As a neurotrophin, BDNF promotes neuronal differentiation, survival during early …
Astrocytic BDNF signaling within the ventromedial hypothalamus regulates energy homeostasis
Brain-derived neurotrophic factor (BDNF) is essential for maintaining energy and glucose
balance within the central nervous system. Because the study of its metabolic actions has …
balance within the central nervous system. Because the study of its metabolic actions has …
Selective deletion of Bdnf in the ventromedial and dorsomedial hypothalamus of adult mice results in hyperphagic behavior and obesity
TJ Unger, GA Calderon, LC Bradley… - Journal of …, 2007 - Soc Neuroscience
Brain-derived neurotrophic factor (BDNF) and its receptor TrkB are expressed in several
hypothalamic and hindbrain nuclei involved in regulating energy homeostasis …
hypothalamic and hindbrain nuclei involved in regulating energy homeostasis …
Obesity: genes, brain, gut, and environment
UN Das - Nutrition, 2010 - Elsevier
Obesity, which is assuming alarming proportions, has been attributed to genetic factors,
hypothalamic dysfunction, and intestinal gut bacteria and an increase in the consumption of …
hypothalamic dysfunction, and intestinal gut bacteria and an increase in the consumption of …
Minireview: steroidogenic factor 1: its roles in differentiation, development, and disease
BP Schimmer, PC White - Molecular endocrinology, 2010 - academic.oup.com
The orphan nuclear receptor steroidogenic factor 1 (SF-1, also called Ad4BP, encoded by
the NR5A1 gene) is an essential regulator of endocrine development and function. Initially …
the NR5A1 gene) is an essential regulator of endocrine development and function. Initially …
Discrete BDNF neurons in the paraventricular hypothalamus control feeding and energy expenditure
Brain-derived neurotrophic factor (BDNF) is a key regulator of energy balance; however, its
underlying mechanism remains unknown. By analyzing BDNF-expressing neurons in …
underlying mechanism remains unknown. By analyzing BDNF-expressing neurons in …
Steroidogenic factor 1 directs programs regulating diet-induced thermogenesis and leptin action in the ventral medial hypothalamic nucleus
KW Kim, L Zhao, J Donato Jr… - Proceedings of the …, 2011 - National Acad Sciences
The transcription factor steroidogenic factor 1 (SF-1) is exclusively expressed in the brain in
the ventral medial hypothalamic nucleus (VMH) and is required for the development of this …
the ventral medial hypothalamic nucleus (VMH) and is required for the development of this …
BDNF and the central control of feeding: accidental bystander or essential player?
M Rios - Trends in neurosciences, 2013 - cell.com
A considerable body of evidence links diminished brain-derived neurotrophic factor (BDNF)
signaling to energy balance dysregulation and severe obesity in humans and rodents …
signaling to energy balance dysregulation and severe obesity in humans and rodents …