The AID/APOBEC polynucleotide cytidine deaminases have historically been classified as
either DNA mutators or RNA editors based on their first identified nucleic acid substrate …

The past several years have seen an explosion in development of applications for the
CRISPR-Cas9 system, from efficient genome editing, to high-throughput screening, to …

Although great progress has been made in the characterization of the off-target effects of
engineered nucleases, sensitive and unbiased genome-wide methods for the detection of …

Defective DNA repair by homologous recombination (HR) is thought to be a major
contributor to tumorigenesis in individuals carrying Brca1 mutations. Here, we show that …

Burkitt's lymphoma is a highly aggressive B-cell non-Hodgkin lymphoma and is the fastest
growing human tumour. The disease is associated with Epstein-Barr virus and was one of …

Double‐strand breaks (DSBs) are the most deleterious DNA lesions, which, if left
unrepaired, may have severe consequences for cell survival, as they lead to chromosome …

DNA double-strand breaks (DSBs) are extremely dangerous lesions with severe
consequences for cell survival and the maintenance of genomic stability. In higher …

Antibody class switching occurs in mature B cells in response to antigen stimulation and
costimulatory signals. It occurs by a unique type of intrachromosomal deletional …

This review summarizes recent evidence concerning molecular changes in the commonest
type of lymphoma, diffuse large-B-cell lymphoma. Detailed studies have revealed three …

DNA double-strand breaks (DSBs) represent a threat to the genome because they can lead
to the loss of genetic information and chromosome rearrangements. The DNA repair protein …