Psychotic depression was initially considered to be at one end of a continuum of severity of
major depression. Subsequent experience demonstrated that psychosis is an independent …

Introduction: Antipsychotic-induced weight-gain (AIWG) is a very important, yet often
neglected side-effect in the treatment with first and second generation antipsychotics. AIWG …

Depression in bipolar disorder (BD) patients presents major clinical challenges. As the
predominant psychopathology even in treated BD, depression is associated not only with …

Objective We investigated the comparative efficacy and tolerability of pharmacological
treatment strategies for the treatment of acute bipolar depression. Data sources A systematic …

Background While clinical trial evidence has firmly established the efficacy of several
atypical antipsychotics (AAPs) for treating bipolar depression, no randomized controlled …

Bipolar disorder (BD) is characterized by mood changes, including recurrent manic,
hypomanic, and depressive episodes, which may involve mixed symptoms. Despite the …

Immunolabeling and autoradiography have traditionally been applied as the methods-of-
choice to visualize and collect molecular information about physiological and pathological …

Dopamine (DA), as one of the major neurotransmitters in the central nervous system (CNS)
and periphery, exerts its actions through five types of receptors which belong to two major …

Depression is the single largest contributor to global disability with a huge economic and
social burden on the world. There are a number of antidepressant drugs on the market, but …

Objective To assess the efficacy, safety, and tolerability of cariprazine in the treatment of the
depressed phase of bipolar I disorder in adults (NCT02670538). Methods In this phase 3 …