Sign-tracking behavior in Pavlovian autoshaping is known to be a relevant index of the
incentive salience attributed to reward-related cues. Evidence has accumulated to suggest …

Gambling and substance use disorders are highly comorbid. Both clinical populations are
impulsive and exhibit risky decision‐making. Drug‐associated cues have long been known …

Impulse control and/or gambling disorders can be triggered by dopamine agonist therapies
used to treat Parkinson9s disease, but the cognitive and neurobiological mechanisms …

The risky decision-making task (RDT) measures risk-taking in a rat model by assessing
preference between a small, safe reward and a large reward with increasing risk of …

Decision-making is always coupled with some level of risk, with more pathological forms of
risk-taking decisions manifesting as gambling disorders. In macaque monkeys trained in a …

Rationale Win-paired stimuli can promote risk taking in experimental gambling paradigms in
both rats and humans. We previously demonstrated that atomoxetine, a noradrenaline …

Decision-making requires that individuals perceive the probabilities and risks associated
with different options. Experimental human and animal laboratory testing provide …

An altered dopamine transmission has been described for different types of addiction for a
long time. Preclinical and clinical evidence support the hypodopaminergic hypothesis and …

Rationale The flashing lights and sounds of modern casinos are alluring and may contribute
to the addictive nature of gambling. Such cues can have a profound impact on the …

Rationale Reward-associated cues can promote maladaptive behavior, including risky
decision-making in a gambling setting. A propensity for sign tracking over goal tracking—ie …