Schistosomiasis, caused mainly by Schistosoma japonicum, S. mansoni, and S.
hematobium, remains one of the most prevalent and serious parasitic diseases worldwide …

Although praziquantel (PZQ) has been used to treat schistosomiasis for over 20 years its
mechanism of action remains unknown. We have developed an assay based on the …

Schistosomes are the only platyhelminths that have evolved separate sexes, and they
exhibit a unique reproductive biology because the female's sexual maturation depends on a …

Eggs produced by the mature female parasite are responsible for the pathogenesis and
transmission of schistosomiasis. Female schistosomes rely on a unique male-induced …

Schistosomes, blood flukes, are an important global public health concern. Paired adult
female schistosomes produce large numbers of eggs that are primarily responsible for the …

Background Schistosoma japonicum is one of the major causative agents of
schistosomiasis. The pairing of males and females leads to female sexual maturation and …

Quantitative real-time polymerase chain reaction (qPCR), as one of the most sensitive and
precise gene expression analysis methods, is frequently used to validate data obtained in …

Background Schistosomiasis remains an important parasitic disease and a major economic
problem in many countries. The Schistosoma mansoni genome and predicted proteome …

Schistosomiasis is a chronic and debilitating disease caused by blood flukes (digenetic
trematodes) of the genus Schistosoma. Schistosomes are sexually dimorphic and exhibit …

Schistosomiasis is one of the most important neglected tropical diseases. Until an effective
vaccine is registered for use, the cornerstone of schistosomiasis control remains …