The goal of this article is to summarize available data examining the physiological
significance of brain corticotropin-releasing factor (CRF) systems in mediating the …

Serotonin1A-receptors (5-HT1A-Rs) are important components of the 5-HT system in the
brain. As somatodendritic autoreceptors they control the activity of 5-HT neurons, and, as …

Rationale: While several environmental situations may produce cocaine craving, there is
little research on whether patterns of drug cue reactivity are similar across different …

Regional brain activation was assessed by mapping of Fos-related protein expression in
rats trained to self-administration of intravenous nicotine and cocaine. Both drugs produced …

There are many sources of reinforcement in the spectrum of cocaine dependence that
contribute to the compulsive cocaine self-administration or loss of control of cocaine intake …

Continued usage of cocaine is determined by genetic, conditioned and homeostatic factors,
while it is reinforced by drug-induced reward and the emotionally negative state of drug …

Scientists have been aware of the existence of a complex relationship between stress and
the subsequent activation of the hypothalamic–pituitary–adrenal (HPA) axis and the …

Participation of the hypothalamo-pituitary-adrenocortical axis, and its primary brain trigger,
corticotropin-releasing factor (CRF) in the control of ingestive behavior can be inferred from …

Over the past decade, data collected in our laboratory have demonstrated that self-
administered cocaine produces Opponent-Process-like behavioral effects. Animals running …

Cocaine stimulates the secretion of corticosterone and ACTH, probably through a CRF-
related mechanism, indicating that the drug activates the HPA axis. Indeed, cocaine has …