Ribosome biogenesis and protein synthesis are fundamental rate-limiting steps for cell
growth and proliferation. The ribosomal proteins (RPs), comprising the structural parts of the …

The pathophysiological mechanism underlying pregnancy complications such as congenital
malformations, miscarriage, preeclampsia, or fetal growth restriction is not entirely known …

The biosynthesis of ribosomes is a complex process that requires the coordinated action of
many factors and a huge energy investment from the cell. Ribosomes are essential for …

The neural crest (NC) is a transient, multipotent and migratory cell population that generates
an astonishingly diverse array of cell types during vertebrate development. These cells …

Many craniofacial disorders are caused by heterozygous mutations in general regulators of
housekeeping cellular functions such as transcription or ribosome biogenesis,. Although it is …

Ribosomes are macromolecular machines that are globally required for the translation of all
proteins in all cells. Ribosome biogenesis, which is essential for cell growth, proliferation …

Ribosomal RNA (rRNA) transcription by RNA polymerase I (Pol I) is a critical rate-limiting
step in ribosome biogenesis, which is essential for cell survival. Despite its global function …

A number of different defects in the process of ribosome production can lead to a diversified
spectrum of disorders that are collectively identified as ribosomopathies. The specific factors …

Ribosome biogenesis is a global process required for growth and proliferation of all cells,
yet perturbation of ribosome biogenesis during human development often leads to tissue …

The spliceosome is a complex of RNA and proteins that function together to identify intron‐
exon junctions in precursor messenger‐RNAs, splice out the introns, and join the flanking …