The process of bone remodeling is the result of the regulated balance between bone cell
populations, namely bone-forming osteoblasts, bone-resorbing osteoclasts, and the …

Cytokines play a pivotal role in maintaining bone homeostasis. Osteoclasts (OCs), the sole
bone resorbing cells, are regulated by numerous cytokines. Macrophage colony-stimulating …

Aging is associated with increased cellular senescence, which is hypothesized to drive the
eventual development of multiple comorbidities. Here we investigate a role for senescent …

Biomaterials with suitable surface modification strategies are contributing significantly to the
rapid development of the field of bone tissue engineering. Despite these encouraging …

Bone and skeletal muscle are integrated organs and their coupling has been considered
mainly a mechanical one in which bone serves as attachment site to muscle while muscle …

The pathogenesis of periodontitis involves a complex immune/inflammatory cascade that is
initiated by the bacteria of the oral biofilm that forms naturally on the teeth. The susceptibility …

As one of the most common metastatic sites of malignancies, bone has a unique
microenvironment that allows metastatic tumor cells to grow and flourish. The fenestrated …

Abstract Bone metastases occur in 50–70% of patients with late-stage breast cancers and
effective therapies are needed. The expression of enhancer of zeste homolog 2 (EZH2) is …

Osteoclasts and osteoblasts dictate skeletal mass, structure, and strength via their respective
roles in resorbing and forming bone. Bone remodeling is a spatially coordinated lifelong …

The past decade has seen an explosion in the field of bone biology. The area of bone
biology over this period of time has been marked by a number of key discoveries that have …