Podocyte injury can disrupt the glomerular filtration barrier (GFB), leading to
podocytopathies that emphasize podocytes as the glomerulus's key organizer. The …

Adaptor proteins play central roles in the assembly of molecular complexes and co-
ordinated activation of specific pathways. Through their modular domain structure, the NCK …

The adaptor proteins NCK1 and NCK2 are well-established signalling nodes that regulate
diverse biological processes including cell proliferation and actin dynamics in many tissue …

C57BL/6 mice are frequently utilized as murine models with the desired genetic background
for altertion in multiple research contexts. So far, there is still a lack of comprehensive kidney …

Podocytes play a critical role in maintaining normal glomerular filtration, and podocyte loss
from the glomerular basement membrane (GBM) initiates and worsens chronic kidney …

Abstract Background/Purpose Oral submucous fibrosis (OSF) is a premalignant condition of
the oral cavity, and its pathogenesis remains largely unknown. A multitude of non-coding …

Altered lysine metabolism in the kidney has been implicated in disease processes. In a new
study, tracking lysine metabolites revealed that lysine metabolism is faster in Dahl rats fed a …