Bacterial specialized metabolites are a proven source of antibiotics and cancer therapies,
but whether we have sampled all the secondary metabolite chemical diversity of cultivated …

The pairing of analytical chemistry with genomic techniques represents a new wave in
natural product chemistry. With an increase in the availability of sequencing and assembly of …

Bacterial secondary metabolites are a major source of antibiotics and other bioactive
compounds. In microbial communities, these molecules can mediate interspecies …

Bioinformatics has become an indispensable tool for natural products research in the
genomic era. One of the key challenges is to accurately convert sequence data of a …

While the field of microbial biogeography has largely focused on the contributions of abiotic
factors to community patterns, the potential influence of biotic interactions in structuring …

Bacterial natural products have found many important industrial applications. Yet traditional
discovery pipelines often prioritize individual natural product families despite the presence …

Covering: 1995 to 2023Advances in bioanalytical methods, particularly mass spectrometry,
have provided valuable molecular insights into the mechanisms of life. Non-targeted …

The study of plant secondary metabolites, now designated as specialized metabolites, is
motivated by multiple scientific objectives, ranging from bioprospecting for bioactive …

There have been significant advances in the flexibility and power of in vitro cell-free
translation systems. The increasing ability to incorporate noncanonical amino acids and …

Genomics-guided methodologies have revolutionized the discovery of natural products.
However, a major challenge in the field of genome mining is determining how to selectively …