Detection of cancer at an early stage when it is still localized improves patient response to
medical interventions for most cancer types. The success of screening tools such as cervical …

in vivo bioluminescence imaging (BLi) is an optical molecular imaging technique used to
visualize molecular and cellular processes in health and diseases and to follow the fate of …

Summary β-Coronaviruses are a family of positive-strand enveloped RNA viruses that
includes the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Much is …

Malignant tumors exhibit heterogeneous metabolic reprogramming, hindering the
identification of translatable vulnerabilities for metabolism-targeted therapy. How molecular …

Abstract Background α-Synuclein (α-Syn), a pathological hallmark of Parkinson's disease
(PD), has been recognized to induce the production of interleukin-1β in a process that …

Inhibition of the vascular endothelial growth factor (VEGF) pathway has failed to improve
overall survival of patients with glioblastoma (GBM). We previously showed that angiopoietin …

Targeted therapy against the programmed cell death ligand-1 (PD-L1) blockade holds
considerable promise for the treatment of different tumor types; however, little effect has …

Liver metastasis is a major cause of mortality for patients with colorectal cancer (CRC).
Mismatch repair–proficient (pMMR) CRCs make up about 95% of metastatic CRCs, and are …

Application of bioluminescence imaging has increased tremendously in the past decade
and has significantly contributed to core conceptual advances in biomedical research. This …

Glioblastoma (GBM) is the most common and malignant primary brain tumor in adults
associated with a poor survival. Current standard of care consists of surgical resection …