[HTML][HTML] T cell receptor (TCR) signaling in health and disease
Interaction of the T cell receptor (TCR) with an MHC-antigenic peptide complex results in
changes at the molecular and cellular levels in T cells. The outside environmental cues are …
changes at the molecular and cellular levels in T cells. The outside environmental cues are …
Store-operated calcium channels
M Prakriya, RS Lewis - Physiological reviews, 2015 - journals.physiology.org
Store-operated calcium channels (SOCs) are a major pathway for calcium signaling in
virtually all metozoan cells and serve a wide variety of functions ranging from gene …
virtually all metozoan cells and serve a wide variety of functions ranging from gene …
Architecture of the mammalian mechanosensitive Piezo1 channel
Piezo proteins are evolutionarily conserved and functionally diverse mechanosensitive
cation channels. However, the overall structural architecture and gating mechanisms of …
cation channels. However, the overall structural architecture and gating mechanisms of …
Diseases caused by mutations in ORAI1 and STIM1
Ca2+ release‐activated Ca2+ (CRAC) channels mediate a specific form of Ca2+ influx
called store‐operated Ca2+ entry (SOCE) that contributes to the function of many cell types …
called store‐operated Ca2+ entry (SOCE) that contributes to the function of many cell types …
STIM proteins: dynamic calcium signal transducers
Stromal interaction molecule (STIM) proteins function in cells as dynamic coordinators of
cellular calcium (Ca2+) signals. Spanning the endoplasmic reticulum (ER) membrane, they …
cellular calcium (Ca2+) signals. Spanning the endoplasmic reticulum (ER) membrane, they …
Crystal structure of the calcium release–activated calcium channel Orai
X Hou, L Pedi, MM Diver, SB Long - Science, 2012 - science.org
The plasma membrane protein Orai forms the pore of the calcium release–activated calcium
(CRAC) channel and generates sustained cytosolic calcium signals when triggered by …
(CRAC) channel and generates sustained cytosolic calcium signals when triggered by …
T cell activation
JE Smith-Garvin, GA Koretzky… - Annual review of …, 2009 - annualreviews.org
This year marks the 25th anniversary of the first Annual Review of Immunology article to
describe features of the T cell antigen receptor (TCR). In celebration of this anniversary, we …
describe features of the T cell antigen receptor (TCR). In celebration of this anniversary, we …
[HTML][HTML] STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1
Store-operated Ca 2+ channels activated by the depletion of Ca 2+ from the endoplasmic
reticulum (ER) are a major Ca 2+ entry pathway in nonexcitable cells and are essential for T …
reticulum (ER) are a major Ca 2+ entry pathway in nonexcitable cells and are essential for T …
The functional network of ion channels in T lymphocytes
MD Cahalan, KG Chandy - Immunological reviews, 2009 - Wiley Online Library
For more than 25 years, it has been widely appreciated that Ca2+ influx is essential to
trigger T‐lymphocyte activation. Patch clamp analysis, molecular identification, and …
trigger T‐lymphocyte activation. Patch clamp analysis, molecular identification, and …
Molecular basis of calcium signaling in lymphocytes: STIM and ORAI
Ca2+ entry into cells of the peripheral immune system occurs through highly Ca2+-selective
channels known as CRAC (calcium release-activated calcium) channels. CRAC channels …
channels known as CRAC (calcium release-activated calcium) channels. CRAC channels …