Cell invasion into the surrounding extracellular matrix or across tissue boundaries and
endothelial barriers occurs in both physiological and pathological scenarios such as …

Epithelial mesenchymal transition (EMT) and mesenchymal epithelial transition (MET) are
genetic determinants of cellular plasticity. These programs operate in physiological …

Cell invasion through basement membrane barriers is crucial during many developmental
processes and in immune surveillance. Dysregulation of invasion also drives the pathology …

The study of the metastatic cascade has revealed the complexity of the process and the
multiple cellular states that disseminated cancer cells must go through. The tumor …

In solid tumours, cancer cells that undergo epithelial mesenchymal transition (EMT) express
characteristic gene expression signatures that promote invasive migration as well as the …

During the metastatic progression, invading cells might achieve degradation and
subsequent invasion into the extracellular matrix (ECM) and the underlying vasculature …

The actin cytoskeleton is a dynamic network that regulates cellular behavior from
development to disease. By rearranging the actin cytoskeleton, cells are capable of …

Scaffold proteins are typically thought of as multi-domain “bridging molecules.” They serve
as crucial regulators of key signaling events by simultaneously binding multiple participants …

Invasive and non-invasive cancer cells can invade together during cooperative invasion.
However, the events leading to it, role of the epithelial-mesenchymal transition and the …

Cancer invasion and metastasis require remodeling of the adjacent extracellular matrix
(ECM). In this mini review, we will cover the mechanisms of proteolytic degradation and the …