Protein cages: from fundamentals to advanced applications
Proteins that self-assemble into polyhedral shell-like structures are useful molecular
containers both in nature and in the laboratory. Here we review efforts to repurpose diverse …
containers both in nature and in the laboratory. Here we review efforts to repurpose diverse …
Biomaterials Facilitating Dendritic Cell‐Mediated Cancer Immunotherapy
Dendritic cell (DC)‐based cancer immunotherapy has exhibited remarkable clinical
prospects because DCs play a central role in initiating and regulating adaptive immune …
prospects because DCs play a central role in initiating and regulating adaptive immune …
Engineering self-assembling protein nanoparticles for therapeutic delivery
A Olshefsky, C Richardson, SH Pun… - Bioconjugate …, 2022 - ACS Publications
Despite remarkable advances over the past several decades, many therapeutic
nanomaterials fail to overcome major in vivo delivery barriers. Controlling immunogenicity …
nanomaterials fail to overcome major in vivo delivery barriers. Controlling immunogenicity …
[HTML][HTML] Engineering nanoparticles to reprogram the tumor immune microenvironment for improved cancer immunotherapy
Immunotherapy is rapidly maturing towards extensive clinical use. However, it does not work
well in large patient populations because of an immunosuppressed microenvironment and …
well in large patient populations because of an immunosuppressed microenvironment and …
NIR-II light evokes DNA cross-linking for chemotherapy and immunogenic cell death
Y Huang, D Wei, B Wang, D Tang, A Cheng, S Xiao… - Acta Biomaterialia, 2023 - Elsevier
As a DNA damaging agent, oxaliplatin (OXA) can induce immunogenic cell death (ICD) in
tumors to activate the immune system. However, the DNA damage induced by OXA is limited …
tumors to activate the immune system. However, the DNA damage induced by OXA is limited …
Biosynthesis of Self‐Assembled Proteinaceous Nanoparticles for Vaccination
C Pan, J Wu, S Qing, X Zhang, L Zhang… - Advanced …, 2020 - Wiley Online Library
Recent years have seen enormous advances in nanovaccines for both prophylactic and
therapeutic applications, but most of these technologies employ chemical or hybrid semi …
therapeutic applications, but most of these technologies employ chemical or hybrid semi …
Advances in encapsulin nanocompartment biology and engineering
JA Jones, TW Giessen - Biotechnology and bioengineering, 2021 - Wiley Online Library
Compartmentalization is an essential feature of all cells. It allows cells to segregate and
coordinate physiological functions in a controlled and ordered manner. Different …
coordinate physiological functions in a controlled and ordered manner. Different …
Nanocaged platforms: modification, drug delivery and nanotoxicity. Opening synthetic cages to release the tiger
Nanocages (NCs) have emerged as a new class of drug-carriers, with a wide range of
possibilities in multi-modality medical treatments and theranostics. Nanocages can …
possibilities in multi-modality medical treatments and theranostics. Nanocages can …
[HTML][HTML] Lactate oxidase/catalase-displaying nanoparticles efficiently consume lactate in the tumor microenvironment to effectively suppress tumor growth
H Choi, M Yeo, Y Kang, HJ Kim, SG Park… - Journal of …, 2023 - Springer
The aggressive proliferation of tumor cells often requires increased glucose uptake and
excessive anaerobic glycolysis, leading to the massive production and secretion of lactate to …
excessive anaerobic glycolysis, leading to the massive production and secretion of lactate to …
Encapsulin cargo loading: progress and potential
JA Jones, R Benisch, TW Giessen - Journal of Materials Chemistry B, 2023 - pubs.rsc.org
Encapsulins are a recently discovered class of prokaryotic self-assembling icosahedral
protein nanocompartments measuring between 24 and 42 nm in diameter, capable of …
protein nanocompartments measuring between 24 and 42 nm in diameter, capable of …